GCLM | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	17 studies	32% ± 11%	Explore
basal cell	8 studies	31% ± 9%	Explore
endothelial cell	6 studies	21% ± 3%	Explore
epithelial cell	6 studies	36% ± 12%	Explore
fibroblast	5 studies	28% ± 9%	Explore
secretory cell	5 studies	32% ± 6%	Explore
pancreatic A cell	4 studies	43% ± 15%	Explore
endothelial cell of vascular tree	4 studies	36% ± 16%	Explore
type B pancreatic cell	3 studies	41% ± 13%	Explore
adipocyte	3 studies	25% ± 3%	Explore
hepatocyte	3 studies	55% ± 27%	Explore
luminal cell of prostate epithelium	3 studies	25% ± 7%	Explore
smooth muscle cell	3 studies	20% ± 5%	Explore
GABAergic neuron	3 studies	39% ± 9%	Explore
glutamatergic neuron	3 studies	49% ± 12%	Explore
pancreatic ductal cell	3 studies	35% ± 14%	Explore
enteroendocrine cell	3 studies	25% ± 3%	Explore
erythrocyte	3 studies	27% ± 6%	Explore
astrocyte	3 studies	22% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
liver	4 studies	32% ± 20%	Explore
pancreas	3 studies	44% ± 8%	Explore
lung	3 studies	32% ± 8%	Explore
prostate	3 studies	29% ± 10%	Explore
brain	3 studies	34% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	1508.02	575 / 578	100%	58.40	1155 / 1155
liver	100%	1910.01	226 / 226	99%	34.30	402 / 406
breast	100%	1398.89	459 / 459	99%	20.28	1102 / 1118
thymus	100%	2079.94	653 / 653	98%	25.54	590 / 605
esophagus	97%	917.94	1408 / 1445	100%	61.76	183 / 183
bladder	100%	1137.43	21 / 21	97%	31.41	489 / 504
brain	99%	995.86	2608 / 2642	98%	12.79	691 / 705
stomach	97%	910.87	349 / 359	98%	16.76	281 / 286
prostate	100%	880.94	244 / 245	96%	12.00	480 / 502
kidney	100%	1467.78	89 / 89	95%	18.29	857 / 901
uterus	98%	562.12	166 / 170	97%	24.36	446 / 459
intestine	96%	840.09	930 / 966	98%	15.44	519 / 527
ovary	94%	569.11	170 / 180	99%	16.48	427 / 430
adrenal gland	100%	3066.76	258 / 258	91%	11.19	209 / 230
pancreas	92%	523.82	303 / 328	97%	15.62	172 / 178
skin	92%	1271.49	1669 / 1809	84%	8.83	398 / 472
adipose	100%	1751.00	1204 / 1204	0%	0	0 / 0
muscle	100%	2234.53	803 / 803	0%	0	0 / 0
spleen	100%	1061.10	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	16.37	1 / 1
blood vessel	99%	823.78	1319 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	34.59	44 / 45
peripheral blood	90%	907.42	839 / 929	0%	0	0 / 0
heart	89%	598.28	764 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	6.17	22 / 29
eye	0%	0	0 / 0	31%	2.06	25 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0035229	Biological process	positive regulation of glutamate-cysteine ligase activity
GO_0006534	Biological process	cysteine metabolic process
GO_0071372	Biological process	cellular response to follicle-stimulating hormone stimulus
GO_0035729	Biological process	cellular response to hepatocyte growth factor stimulus
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0051409	Biological process	response to nitrosative stress
GO_0014823	Biological process	response to activity
GO_0006750	Biological process	glutathione biosynthetic process
GO_0097746	Biological process	blood vessel diameter maintenance
GO_0006536	Biological process	glutamate metabolic process
GO_0008637	Biological process	apoptotic mitochondrial changes
GO_0051900	Biological process	regulation of mitochondrial depolarization
GO_0097069	Biological process	cellular response to thyroxine stimulus
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0044752	Biological process	response to human chorionic gonadotropin
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0006979	Biological process	response to oxidative stress
GO_0044344	Biological process	cellular response to fibroblast growth factor stimulus
GO_0035733	Biological process	hepatic stellate cell activation
GO_0005829	Cellular component	cytosol
GO_0017109	Cellular component	glutamate-cysteine ligase complex
GO_0044877	Molecular function	protein-containing complex binding
GO_0035226	Molecular function	glutamate-cysteine ligase catalytic subunit binding
GO_0004357	Molecular function	glutamate-cysteine ligase activity
GO_0030234	Molecular function	enzyme regulator activity
GO_0005515	Molecular function	protein binding

Gene name	GCLM
Protein name	Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)
Synonyms	GLCLR
Description
Accessions	ENST00000615724.1 [P48507-2] ENST00000370238.8 [P48507-1] P48507

GCLM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review