GBP7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GBP7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GBP7 at tissue level.

III. Associated gene sets

GO_0051715Biological processcytolysis in another organism
GO_0034345Biological processnegative regulation of type III interferon production
GO_0051607Biological processdefense response to virus
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0042832Biological processdefense response to protozoan
GO_0046426Biological processnegative regulation of receptor signaling pathway via JAK-STAT
GO_0045070Biological processpositive regulation of viral genome replication
GO_0042742Biological processdefense response to bacterium
GO_0071346Biological processcellular response to type II interferon
GO_0001818Biological processnegative regulation of cytokine production
GO_0032480Biological processnegative regulation of type I interferon production
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005525Molecular functionGTP binding
GO_0003924Molecular functionGTPase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGBP7
Protein nameGuanylate-binding protein 7 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 7) (GBP-7) (Guanine nucleotide-binding protein 7) (Guanylate-binding protein 4-like)
Guanylate binding protein 7
SynonymsGBP4L
DescriptionFUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP to GMP in two consecutive cleavage reactions and predominantly uses GTP and not GDP or GMP as the substrate (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Also promotes IFN-gamma-mediated host defense against bacterial infections by regulating oxidative responses and bacteriolytic peptide generation (By similarity). May help to assemble NADPH oxidase on phagosomal membranes by acting as a bridging protein between NADPH oxidase cytosolic subunits NCF2-NCF4 and the membrane subunits CYBA-CYBB (By similarity). Participates along with GBP1 in trafficking monoubiquinated protein cargo to autolysosomes for generating ubiquitin-derived antimicrobial peptides (By similarity). Facilitates influenza A virus replication by inhibiting the activation of NF-kappaB and JAK-STAT signaling pathways and the expression of type I, type III interferons and pro-inflammatory cytokines . Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite (By similarity). .

AccessionsENST00000650452.1
Q8N8V2
ENST00000294671.3
A0A3B3IRS3