FOXN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FOXN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXN4 at tissue level.

III. Associated gene sets

GO_0036302Biological processatrioventricular canal development
GO_0001947Biological processheart looping
GO_0008016Biological processregulation of heart contraction
GO_0021514Biological processventral spinal cord interneuron differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060579Biological processventral spinal cord interneuron fate commitment
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035881Biological processamacrine cell differentiation
GO_0010842Biological processretina layer formation
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameFOXN4
Protein nameForkhead box N4
Forkhead box protein N4
FOXN4 protein
Synonyms
DescriptionFUNCTION: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). .

AccessionsA6H901
S4R3U5
Q96NZ1
ENST00000299162.10 [Q96NZ1-1]
A4FUA3
A0A0C4DG65
ENST00000423960.1
ENST00000355216.5 [Q96NZ1-3]
ENST00000468516.1