FOXI1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXI1 at tissue level.

III. Associated gene sets

GO_0042472Biological processinner ear morphogenesis
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_0030154Biological processcell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0009653Biological processanatomical structure morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005730Cellular componentnucleolus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0008301Molecular functionDNA binding, bending
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameFOXI1
Protein nameForkhead box I1
Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3)
SynonymshCG_36987
FKHL10
FREAC6
DescriptionFUNCTION: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). .

AccessionsE0XEY9
ENST00000306268.8 [Q12951-1]
E0XEN6
Q12951
ENST00000449804.4 [Q12951-2]