FHOD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FHOD1 at tissue level.

III. Associated gene sets

GO_0030866Biological processcortical actin cytoskeleton organization
GO_0051492Biological processregulation of stress fiber assembly
GO_0051660Biological processestablishment of centrosome localization
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007097Biological processnuclear migration
GO_0032059Cellular componentbleb
GO_0001725Cellular componentstress fiber
GO_0005856Cellular componentcytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0014704Cellular componentintercalated disc
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0051015Molecular functionactin filament binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFHOD1
Protein nameFH1/FH2 domain-containing protein 1 variant
FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1)
Formin homology 2 domain containing 1
SynonymsFHOS
FHOS1
DescriptionFUNCTION: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. .

AccessionsA0A068F7M9
ENST00000258201.9
J3KTH7
ENST00000567561.1
J3KT53
ENST00000568595.1
ENST00000567509.1
J3QR24
ENST00000561922.1
Q9Y613
H3BVE7