Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 29 studies | 32% ± 15% | |
macrophage | 22 studies | 37% ± 20% | |
glutamatergic neuron | 10 studies | 39% ± 24% | |
type I pneumocyte | 9 studies | 30% ± 12% | |
fibroblast | 9 studies | 23% ± 8% | |
endothelial cell of lymphatic vessel | 8 studies | 29% ± 12% | |
microglial cell | 8 studies | 30% ± 9% | |
oligodendrocyte precursor cell | 8 studies | 29% ± 14% | |
myeloid cell | 8 studies | 35% ± 18% | |
astrocyte | 8 studies | 28% ± 13% | |
oligodendrocyte | 8 studies | 28% ± 11% | |
type II pneumocyte | 7 studies | 34% ± 12% | |
pericyte | 7 studies | 22% ± 6% | |
epithelial cell | 7 studies | 34% ± 16% | |
interneuron | 6 studies | 36% ± 20% | |
GABAergic neuron | 6 studies | 39% ± 16% | |
smooth muscle cell | 5 studies | 21% ± 2% | |
squamous epithelial cell | 4 studies | 43% ± 19% | |
neuron | 4 studies | 30% ± 9% | |
dendritic cell | 4 studies | 26% ± 4% | |
endothelial cell of artery | 4 studies | 19% ± 3% | |
ciliated cell | 4 studies | 28% ± 5% | |
capillary endothelial cell | 4 studies | 24% ± 8% | |
club cell | 4 studies | 30% ± 8% | |
erythrocyte | 4 studies | 43% ± 22% | |
monocyte | 4 studies | 34% ± 5% | |
mononuclear phagocyte | 3 studies | 33% ± 13% | |
vein endothelial cell | 3 studies | 39% ± 22% | |
endothelial cell of vascular tree | 3 studies | 36% ± 20% | |
alveolar macrophage | 3 studies | 49% ± 8% | |
basal cell | 3 studies | 38% ± 17% | |
adipocyte | 3 studies | 23% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 4027.30 | 578 / 578 | 99% | 26.10 | 1147 / 1155 |
esophagus | 100% | 3202.31 | 1445 / 1445 | 99% | 25.04 | 181 / 183 |
kidney | 100% | 1860.37 | 89 / 89 | 99% | 34.33 | 890 / 901 |
breast | 100% | 3393.98 | 459 / 459 | 98% | 24.30 | 1092 / 1118 |
prostate | 100% | 2099.80 | 244 / 245 | 97% | 19.60 | 489 / 502 |
thymus | 100% | 3491.61 | 653 / 653 | 97% | 36.72 | 585 / 605 |
stomach | 99% | 1595.52 | 357 / 359 | 97% | 21.17 | 278 / 286 |
uterus | 100% | 3354.04 | 170 / 170 | 97% | 17.42 | 443 / 459 |
brain | 97% | 1183.29 | 2562 / 2642 | 99% | 17.13 | 699 / 705 |
intestine | 100% | 2685.60 | 966 / 966 | 96% | 20.00 | 506 / 527 |
bladder | 100% | 2370.90 | 21 / 21 | 95% | 17.10 | 480 / 504 |
pancreas | 95% | 1046.59 | 313 / 328 | 97% | 22.11 | 172 / 178 |
ovary | 100% | 2523.38 | 180 / 180 | 92% | 11.15 | 394 / 430 |
liver | 99% | 1006.00 | 224 / 226 | 84% | 11.05 | 342 / 406 |
skin | 100% | 2427.09 | 1808 / 1809 | 82% | 11.81 | 389 / 472 |
adrenal gland | 100% | 1521.44 | 257 / 258 | 82% | 8.97 | 189 / 230 |
blood vessel | 100% | 3185.66 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2814.89 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 3769.17 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 1509.00 | 798 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1243.64 | 835 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 17.78 | 42 / 45 |
lymph node | 0% | 0 | 0 / 0 | 76% | 11.17 | 22 / 29 |
peripheral blood | 55% | 737.14 | 512 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 53% | 6.36 | 42 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048488 | Biological process | synaptic vesicle endocytosis |
GO_0010324 | Biological process | membrane invagination |
GO_0072583 | Biological process | clathrin-dependent endocytosis |
GO_0048268 | Biological process | clathrin coat assembly |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0098835 | Cellular component | presynaptic endocytic zone membrane |
GO_0005829 | Cellular component | cytosol |
GO_0030136 | Cellular component | clathrin-coated vesicle |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0001786 | Molecular function | phosphatidylserine binding |
GO_0005515 | Molecular function | protein binding |
GO_0035091 | Molecular function | phosphatidylinositol binding |
Gene name | FCHO2 |
Protein name | F-BAR domain only protein 2 FCHO2 protein FCH and mu domain containing endocytic adaptor 2 |
Synonyms | |
Description | FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. . |
Accessions | ENST00000430046.7 [Q0JRZ9-1] ENST00000287761.7 ENST00000512348.5 [Q0JRZ9-3] A0JLQ4 Q0JRZ9 H0YAE2 ENST00000507345.6 H7BXJ4 |