FCHO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048488Biological processsynaptic vesicle endocytosis
GO_0010324Biological processmembrane invagination
GO_0072583Biological processclathrin-dependent endocytosis
GO_0048268Biological processclathrin coat assembly
GO_0072659Biological processprotein localization to plasma membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0098835Cellular componentpresynaptic endocytic zone membrane
GO_0005829Cellular componentcytosol
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0042802Molecular functionidentical protein binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameFCHO2
Protein nameF-BAR domain only protein 2
FCHO2 protein
FCH and mu domain containing endocytic adaptor 2
Synonyms
DescriptionFUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. .

AccessionsENST00000430046.7 [Q0JRZ9-1]
ENST00000287761.7
ENST00000512348.5 [Q0JRZ9-3]
A0JLQ4
Q0JRZ9
H0YAE2
ENST00000507345.6
H7BXJ4