FASTK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044528Biological processregulation of mitochondrial mRNA stability
GO_0043484Biological processregulation of RNA splicing
GO_0097190Biological processapoptotic signaling pathway
GO_0000963Biological processmitochondrial RNA processing
GO_0006468Biological processprotein phosphorylation
GO_0035770Cellular componentribonucleoprotein granule
GO_0005759Cellular componentmitochondrial matrix
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0033867Molecular functionFas-activated serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameFASTK
Protein nameFAST kinase
FASTK protein
Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8)
Synonymstcag7.769
DescriptionFUNCTION: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. .; FUNCTION: [Isoform 4]: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. .

AccessionsENST00000482571.2 [Q14296-3]
Q14296
ENST00000353841.6 [Q14296-2]
Q9BWD7
A0A090N8Z7
ENST00000297532.11 [Q14296-1]
A0A090N8I0