FAN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006289Biological processnucleotide-excision repair
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006281Biological processDNA repair
GO_0036297Biological processinterstrand cross-link repair
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045171Cellular componentintercellular bridge
GO_0005634Cellular componentnucleus
GO_0070336Molecular functionflap-structured DNA binding
GO_0008409Molecular function5'-3' exonuclease activity
GO_0004528Molecular functionphosphodiesterase I activity
GO_0005515Molecular functionprotein binding
GO_0017108Molecular function5'-flap endonuclease activity
GO_0140036Molecular functionubiquitin-modified protein reader activity
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameFAN1
Protein nameFanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)
FANCD2 and FANCI associated nuclease 1
Fanconi-associated nuclease (EC 3.1.4.1)
FANCD2/FANCI-associated nuclease 1 isoform B
SynonymsKIAA1018
MTMR15
DescriptionFUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates . Not involved in DNA double-strand breaks resection . Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL . Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap . Also has endonuclease activity toward 5'-flaps . .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

FUNCTION: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. .

AccessionsA0A590UJF5
ENST00000561594.5 [Q9Y2M0-2]
ENST00000565466.5 [Q9Y2M0-2]
ENST00000666143.1
A0A590UK78
Q9Y2M0
ENST00000670074.1
ENST00000658773.1 [Q9Y2M0-2]
D9MXF4
ENST00000657391.1 [Q9Y2M0-1]
ENST00000670849.1 [Q9Y2M0-1]
ENST00000654056.1
A0A590UJ38
ENST00000362065.9 [Q9Y2M0-1]
ENST00000562892.2
ENST00000664070.1
ENST00000656435.1 [Q9Y2M0-1]
X5D9F0
ENST00000661974.1
ENST00000621063.1 [Q9Y2M0-1]
A0A590UKC0
H3BQ24
X5D7V8
ENST00000561607.6 [Q9Y2M0-2]
ENST00000565280.5
A0A590UJL5
ENST00000664837.1
X5DRB9
H3BUK3