FAM89B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0030335Biological processpositive regulation of cell migration
GO_0060392Biological processnegative regulation of SMAD protein signal transduction
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0030027Cellular componentlamellipodium
GO_0005737Cellular componentcytoplasm
GO_0001222Molecular functiontranscription corepressor binding

IV. Literature review

[source]
Gene nameFAM89B
Protein nameLeucine repeat adapter protein 25
SynonymsLrap25
DescriptionFUNCTION: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. .

AccessionsENST00000449319.2 [Q8N5H3-4]
ENST00000316409.2 [Q8N5H3-1]
Q8N5H3
ENST00000530349.2 [Q8N5H3-3]