FAM111A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016540Biological processprotein autoprocessing
GO_0006974Biological processDNA damage response
GO_0031297Biological processreplication fork processing
GO_0045071Biological processnegative regulation of viral genome replication
GO_0006508Biological processproteolysis
GO_0006260Biological processDNA replication
GO_0106300Biological processprotein-DNA covalent cross-linking repair
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0001650Cellular componentfibrillar center
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding

IV. Literature review

[source]
Gene nameFAM111A
Protein nameSerine protease FAM111A (EC 3.4.21.-)
Serine protease FAM111A
FAM111 trypsin like peptidase A
SynonymsKIAA1895
DescriptionFUNCTION: Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity . DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde . Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors . Required for PCNA loading on replication sites . Promotes S-phase entry and DNA synthesis . Acts also as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus . Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity . In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy . .

AccessionsA0A804HLI8
ENST00000682018.1
ENST00000531408.6
ENST00000528737.5
A0A6Q8PF34
ENST00000527629.6
ENST00000676459.1
ENST00000531147.1
ENST00000676340.1
ENST00000361723.7
E9PNQ0
ENST00000674617.1
ENST00000675806.2
E9PR18
ENST00000527629
A0A6Q8PHI8
Q96PZ2
ENST00000531408
ENST00000684135.1
ENST00000529985.3
ENST00000675806
ENST00000529985
ENST00000675163.1
ENST00000533703.1
ENST00000420244.6