Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 9 studies | 21% ± 5% | |
CD8-positive, alpha-beta T cell | 8 studies | 21% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 7 studies | 18% ± 2% | |
B cell | 5 studies | 19% ± 3% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 18% ± 3% | |
epithelial cell | 5 studies | 30% ± 9% | |
ciliated cell | 5 studies | 21% ± 7% | |
endothelial cell | 5 studies | 23% ± 5% | |
macrophage | 5 studies | 19% ± 3% | |
gamma-delta T cell | 5 studies | 19% ± 6% | |
classical monocyte | 4 studies | 24% ± 8% | |
lymphocyte | 4 studies | 20% ± 2% | |
T cell | 3 studies | 17% ± 2% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 0% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 17% ± 2% | |
mature NK T cell | 3 studies | 18% ± 3% | |
non-classical monocyte | 3 studies | 19% ± 5% | |
glomerular endothelial cell | 3 studies | 18% ± 2% | |
pro-B cell | 3 studies | 29% ± 5% | |
dendritic cell | 3 studies | 24% ± 5% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 3 studies | 25% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 7409.20 | 245 / 245 | 100% | 45.08 | 502 / 502 |
esophagus | 100% | 2563.01 | 1441 / 1445 | 100% | 21.91 | 183 / 183 |
intestine | 100% | 4067.15 | 966 / 966 | 100% | 19.39 | 525 / 527 |
lung | 100% | 5873.79 | 578 / 578 | 100% | 20.63 | 1150 / 1155 |
thymus | 100% | 6579.26 | 653 / 653 | 100% | 34.04 | 602 / 605 |
breast | 100% | 3953.25 | 458 / 459 | 99% | 27.96 | 1112 / 1118 |
uterus | 100% | 4015.47 | 170 / 170 | 99% | 25.05 | 455 / 459 |
bladder | 100% | 3276.95 | 21 / 21 | 99% | 21.65 | 498 / 504 |
ovary | 100% | 3174.91 | 180 / 180 | 99% | 15.85 | 424 / 430 |
kidney | 100% | 3805.88 | 89 / 89 | 98% | 19.48 | 885 / 901 |
stomach | 100% | 3212.02 | 358 / 359 | 98% | 18.63 | 281 / 286 |
pancreas | 99% | 1916.00 | 326 / 328 | 97% | 19.31 | 172 / 178 |
skin | 100% | 3435.10 | 1804 / 1809 | 90% | 16.98 | 426 / 472 |
liver | 98% | 1904.31 | 222 / 226 | 84% | 9.46 | 340 / 406 |
adrenal gland | 99% | 3967.83 | 256 / 258 | 68% | 5.89 | 157 / 230 |
brain | 48% | 498.40 | 1279 / 2642 | 94% | 14.01 | 660 / 705 |
lymph node | 0% | 0 | 0 / 0 | 100% | 31.91 | 29 / 29 |
spleen | 100% | 8810.88 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 25.52 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.80 | 1 / 1 |
adipose | 100% | 3363.81 | 1202 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 98% | 2333.67 | 1304 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 3335.78 | 854 / 929 | 0% | 0 | 0 / 0 |
heart | 91% | 1389.54 | 785 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 39% | 3.06 | 31 / 80 |
muscle | 26% | 238.41 | 205 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016540 | Biological process | protein autoprocessing |
GO_0006974 | Biological process | DNA damage response |
GO_0031297 | Biological process | replication fork processing |
GO_0045071 | Biological process | negative regulation of viral genome replication |
GO_0006508 | Biological process | proteolysis |
GO_0006260 | Biological process | DNA replication |
GO_0106300 | Biological process | protein-DNA covalent cross-linking repair |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005737 | Cellular component | cytoplasm |
GO_0001650 | Cellular component | fibrillar center |
GO_0005634 | Cellular component | nucleus |
GO_0008233 | Molecular function | peptidase activity |
GO_0005515 | Molecular function | protein binding |
GO_0003697 | Molecular function | single-stranded DNA binding |
Gene name | FAM111A |
Protein name | Serine protease FAM111A (EC 3.4.21.-) Serine protease FAM111A FAM111 trypsin like peptidase A |
Synonyms | KIAA1895 |
Description | FUNCTION: Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity . DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde . Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors . Required for PCNA loading on replication sites . Promotes S-phase entry and DNA synthesis . Acts also as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus . Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity . In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy . . |
Accessions | A0A804HLI8 ENST00000682018.1 ENST00000531408.6 ENST00000528737.5 A0A6Q8PF34 ENST00000527629.6 ENST00000676459.1 ENST00000531147.1 ENST00000676340.1 ENST00000361723.7 E9PNQ0 ENST00000674617.1 ENST00000675806.2 E9PR18 ENST00000527629 A0A6Q8PHI8 Q96PZ2 ENST00000531408 ENST00000684135.1 ENST00000529985.3 ENST00000675806 ENST00000529985 ENST00000675163.1 ENST00000533703.1 ENST00000420244.6 |