FAAP24 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FAAP24 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FAAP24 at tissue level.

III. Associated gene sets

GO_0036297Biological processinterstrand cross-link repair
GO_0043240Cellular componentFanconi anaemia nuclear complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0071821Cellular componentFANCM-MHF complex
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameFAAP24
Protein nameFA core complex associated protein 24
Chromosome 19 open reading frame 40 isoform 2 (FA core complex associated protein 24)
Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa)
Chromosome 19 open reading frame 40 isoform 1
SynonymsC19orf40
DescriptionFUNCTION: Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. .

AccessionsK7EKQ4
ENST00000590281.1
ENST00000588258.6
Q9BTP7
ENST00000590179.1
X6R368
ENST00000589646.5
ENST00000254262.9
ENST00000699960.1
A0A0S2Z5V6