Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 14 studies | 46% ± 23% | |
basal cell | 10 studies | 35% ± 21% | |
adipocyte | 9 studies | 40% ± 13% | |
oligodendrocyte precursor cell | 7 studies | 28% ± 10% | |
macrophage | 7 studies | 29% ± 11% | |
ciliated cell | 5 studies | 28% ± 8% | |
retinal cone cell | 4 studies | 21% ± 5% | |
secretory cell | 3 studies | 21% ± 4% | |
epithelial cell | 3 studies | 42% ± 26% | |
respiratory goblet cell | 3 studies | 46% ± 10% | |
glutamatergic neuron | 3 studies | 36% ± 25% | |
club cell | 3 studies | 31% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2928.74 | 245 / 245 | 99% | 50.90 | 499 / 502 |
uterus | 91% | 794.91 | 155 / 170 | 83% | 80.43 | 381 / 459 |
thymus | 100% | 1865.48 | 653 / 653 | 73% | 25.68 | 439 / 605 |
breast | 100% | 1351.62 | 457 / 459 | 57% | 19.05 | 632 / 1118 |
esophagus | 84% | 1532.55 | 1211 / 1445 | 55% | 19.25 | 100 / 183 |
brain | 78% | 510.61 | 2062 / 2642 | 52% | 14.35 | 369 / 705 |
ovary | 10% | 43.21 | 18 / 180 | 92% | 104.58 | 394 / 430 |
lung | 49% | 206.31 | 286 / 578 | 50% | 25.62 | 574 / 1155 |
kidney | 88% | 394.89 | 78 / 89 | 11% | 1.90 | 96 / 901 |
stomach | 74% | 505.77 | 267 / 359 | 18% | 6.07 | 51 / 286 |
intestine | 72% | 582.34 | 697 / 966 | 14% | 4.11 | 76 / 527 |
adipose | 85% | 809.92 | 1023 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 80% | 54.78 | 36 / 45 |
bladder | 33% | 243.57 | 7 / 21 | 42% | 19.49 | 214 / 504 |
blood vessel | 76% | 399.36 | 1011 / 1335 | 0% | 0 | 0 / 0 |
skin | 72% | 405.67 | 1294 / 1809 | 3% | 0.49 | 14 / 472 |
pancreas | 9% | 25.77 | 31 / 328 | 40% | 9.64 | 72 / 178 |
heart | 43% | 217.50 | 370 / 861 | 0% | 0 | 0 / 0 |
muscle | 25% | 87.68 | 202 / 803 | 0% | 0 | 0 / 0 |
liver | 21% | 71.32 | 48 / 226 | 2% | 0.44 | 9 / 406 |
lymph node | 0% | 0 | 0 / 0 | 21% | 5.26 | 6 / 29 |
adrenal gland | 11% | 58.86 | 28 / 258 | 2% | 0.44 | 5 / 230 |
eye | 0% | 0 | 0 / 0 | 4% | 0.95 | 3 / 80 |
spleen | 4% | 10.51 | 9 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 3% | 39.07 | 31 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0097345 | Biological process | mitochondrial outer membrane permeabilization |
GO_0007501 | Biological process | mesodermal cell fate specification |
GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
GO_0048856 | Biological process | anatomical structure development |
GO_0006281 | Biological process | DNA repair |
GO_0014706 | Biological process | striated muscle tissue development |
GO_0030154 | Biological process | cell differentiation |
GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
GO_0006338 | Biological process | chromatin remodeling |
GO_0045739 | Biological process | positive regulation of DNA repair |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005739 | Cellular component | mitochondrion |
GO_0005634 | Cellular component | nucleus |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
GO_0140793 | Molecular function | histone H2AXY142 phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0000287 | Molecular function | magnesium ion binding |
Gene name | EYA2 |
Protein name | Eyes absent 2 EYA2B Eyes absent homolog 2 (EC 3.1.3.48) Putative regulatory uORF Alternative protein EYA2 Eyes absent homolog (EC 3.1.3.48) |
Synonyms | EAB1 |
Description | FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 . . |
Accessions | L0R6G3 Q96J96 ENST00000317304.10 B1AKW3 ENST00000327619.10 [O00167-1] Q8WXB5 ENST00000458636.2 O00167 Q66T69 ENST00000357410.7 [O00167-3] Q96J97 E7ETN2 ENST00000611592.4 ENST00000497062.6 [O00167-2] |