EYA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097345Biological processmitochondrial outer membrane permeabilization
GO_0007501Biological processmesodermal cell fate specification
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0048856Biological processanatomical structure development
GO_0006281Biological processDNA repair
GO_0014706Biological processstriated muscle tissue development
GO_0030154Biological processcell differentiation
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0006338Biological processchromatin remodeling
GO_0045739Biological processpositive regulation of DNA repair
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004725Molecular functionprotein tyrosine phosphatase activity
GO_0140793Molecular functionhistone H2AXY142 phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameEYA2
Protein nameEyes absent 2
EYA2B
Eyes absent homolog 2 (EC 3.1.3.48)
Putative regulatory uORF
Alternative protein EYA2
Eyes absent homolog (EC 3.1.3.48)
SynonymsEAB1
DescriptionFUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 . .

AccessionsL0R6G3
Q96J96
ENST00000317304.10
B1AKW3
ENST00000327619.10 [O00167-1]
Q8WXB5
ENST00000458636.2
O00167
Q66T69
ENST00000357410.7 [O00167-3]
Q96J97
E7ETN2
ENST00000611592.4
ENST00000497062.6 [O00167-2]