Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 13 studies | 41% ± 19% | |
| cardiac muscle cell | 4 studies | 22% ± 1% | |
| basal cell | 4 studies | 33% ± 17% | |
| ciliated cell | 4 studies | 46% ± 22% | |
| ependymal cell | 3 studies | 49% ± 3% | |
| respiratory goblet cell | 3 studies | 33% ± 17% |
Insufficient scRNA-seq data for expression of EYA1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1689.55 | 245 / 245 | 77% | 2.82 | 387 / 502 |
| brain | 78% | 654.52 | 2061 / 2642 | 85% | 8.17 | 597 / 705 |
| thymus | 87% | 149.19 | 570 / 653 | 14% | 3.08 | 82 / 605 |
| heart | 91% | 381.43 | 784 / 861 | 0% | 0 | 0 / 0 |
| muscle | 89% | 293.80 | 714 / 803 | 0% | 0 | 0 / 0 |
| bladder | 71% | 436.90 | 15 / 21 | 8% | 0.33 | 41 / 504 |
| stomach | 53% | 118.52 | 191 / 359 | 12% | 0.61 | 33 / 286 |
| lung | 36% | 95.54 | 206 / 578 | 29% | 1.07 | 332 / 1155 |
| skin | 8% | 13.26 | 153 / 1809 | 49% | 6.84 | 231 / 472 |
| uterus | 16% | 90.48 | 28 / 170 | 24% | 2.29 | 109 / 459 |
| breast | 28% | 31.85 | 128 / 459 | 12% | 0.65 | 130 / 1118 |
| adrenal gland | 6% | 13.01 | 16 / 258 | 29% | 1.49 | 67 / 230 |
| esophagus | 22% | 25.02 | 317 / 1445 | 11% | 0.28 | 21 / 183 |
| intestine | 10% | 9.71 | 96 / 966 | 10% | 0.61 | 54 / 527 |
| kidney | 7% | 5.28 | 6 / 89 | 12% | 0.42 | 107 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 1.10 | 8 / 45 |
| ovary | 6% | 5.67 | 11 / 180 | 12% | 0.70 | 50 / 430 |
| adipose | 14% | 15.45 | 167 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 5% | 5.84 | 13 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 4% | 4.99 | 53 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 3% | 0.25 | 6 / 178 |
| liver | 0% | 0 | 0 / 226 | 3% | 0.08 | 13 / 406 |
| peripheral blood | 0% | 0.42 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042473 | Biological process | outer ear morphogenesis |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0045664 | Biological process | regulation of neuron differentiation |
| GO_0060037 | Biological process | pharyngeal system development |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0016925 | Biological process | protein sumoylation |
| GO_0001658 | Biological process | branching involved in ureteric bud morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0014706 | Biological process | striated muscle tissue development |
| GO_0010212 | Biological process | response to ionizing radiation |
| GO_0072513 | Biological process | positive regulation of secondary heart field cardioblast proliferation |
| GO_0045739 | Biological process | positive regulation of DNA repair |
| GO_0006302 | Biological process | double-strand break repair |
| GO_0001656 | Biological process | metanephros development |
| GO_0048704 | Biological process | embryonic skeletal system morphogenesis |
| GO_0048665 | Biological process | neuron fate specification |
| GO_0090103 | Biological process | cochlea morphogenesis |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0048752 | Biological process | semicircular canal morphogenesis |
| GO_0030154 | Biological process | cell differentiation |
| GO_0071600 | Biological process | otic vesicle morphogenesis |
| GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0035909 | Biological process | aorta morphogenesis |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0007501 | Biological process | mesodermal cell fate specification |
| GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0042474 | Biological process | middle ear morphogenesis |
| GO_0048856 | Biological process | anatomical structure development |
| GO_0007389 | Biological process | pattern specification process |
| GO_0032993 | Cellular component | protein-DNA complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140793 | Molecular function | histone H2AXY142 phosphatase activity |
| GO_0017018 | Molecular function | myosin phosphatase activity |
| GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EYA1 |
| Protein name | Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) EYA transcriptional coactivator and phosphatase 1 Eyes absent homolog (EC 3.1.3.48) |
| Synonyms | |
| Description | FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity). . |
| Accessions | Q99502 A0A2R8YET7 ENST00000645793.1 [Q99502-1] ENST00000645451.1 A0A2R8YF73 F8WB53 E5RIQ7 Q0P517 ENST00000647540.1 [Q99502-1] A0A2R8Y6K4 A0A2R8YGM9 ENST00000642391.1 ENST00000493349.2 ENST00000388742.8 [Q99502-1] A0A2R8YFS6 ENST00000644229.1 ENST00000340726.8 [Q99502-1] E5RHZ7 ENST00000643681.1 ENST00000388740.4 [Q99502-2] ENST00000388743.6 ENST00000303824.11 E7EQM5 Q4A4D0 ENST00000388741.7 ENST00000419131.6 [Q99502-3] ENST00000644712.1 ENST00000465115.6 A6NCB9 |
