EXOSC4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EXOSC4 at tissue level.

III. Associated gene sets

GO_0030307Biological processpositive regulation of cell growth
GO_0006396Biological processRNA processing
GO_0034475Biological processU4 snRNA 3'-end processing
GO_0071051Biological processpoly(A)-dependent snoRNA 3'-end processing
GO_0051607Biological processdefense response to virus
GO_0071044Biological processhistone mRNA catabolic process
GO_0006401Biological processRNA catabolic process
GO_0016075Biological processrRNA catabolic process
GO_0071028Biological processnuclear mRNA surveillance
GO_0000460Biological processmaturation of 5.8S rRNA
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0006364Biological processrRNA processing
GO_0045006Biological processDNA deamination
GO_0005730Cellular componentnucleolus
GO_0000178Cellular componentexosome (RNase complex)
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0101019Cellular componentnucleolar exosome (RNase complex)
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005634Cellular componentnucleus
GO_0004532Molecular functionRNA exonuclease activity
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXOSC4
Protein nameExosome component 4
Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)
SynonymsRRP41
SKI6
DescriptionFUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. .

AccessionsE9PI41
ENST00000316052.6
ENST00000525936.1
ENST00000527954.1
E9PPI9
Q9NPD3