EXOSC3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EXOSC3 at tissue level.

III. Associated gene sets

GO_0071038Biological processTRAMP-dependent tRNA surveillance pathway
GO_0006402Biological processmRNA catabolic process
GO_0071035Biological processnuclear polyadenylation-dependent rRNA catabolic process
GO_0045830Biological processpositive regulation of isotype switching
GO_0006396Biological processRNA processing
GO_0034475Biological processU4 snRNA 3'-end processing
GO_0071051Biological processpoly(A)-dependent snoRNA 3'-end processing
GO_0006401Biological processRNA catabolic process
GO_0045006Biological processDNA deamination
GO_0071034Biological processCUT catabolic process
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0045190Biological processisotype switching
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0006364Biological processrRNA processing
GO_0000467Biological processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0005730Cellular componentnucleolus
GO_0000178Cellular componentexosome (RNase complex)
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0101019Cellular componentnucleolar exosome (RNase complex)
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005634Cellular componentnucleus
GO_0004532Molecular functionRNA exonuclease activity
GO_0003723Molecular functionRNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXOSC3
Protein nameExosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)
Exosome component 3
SynonymsCGI-102
RRP40
DescriptionFUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5. .

AccessionsENST00000327304.10 [Q9NQT5-1]
ENST00000396521.3 [Q9NQT5-2]
ENST00000678095.1
A0A7I2V328
ENST00000679059.1 [Q9NQT5-2]
Q9NQT5
ENST00000465229.5 [Q9NQT5-2]