EXOSC10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0071038Biological processTRAMP-dependent tRNA surveillance pathway
GO_0071040Biological processnuclear polyadenylation-dependent antisense transcript catabolic process
GO_0071035Biological processnuclear polyadenylation-dependent rRNA catabolic process
GO_0006396Biological processRNA processing
GO_0071051Biological processpoly(A)-dependent snoRNA 3'-end processing
GO_0071044Biological processhistone mRNA catabolic process
GO_0071036Biological processnuclear polyadenylation-dependent snoRNA catabolic process
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0006401Biological processRNA catabolic process
GO_0042274Biological processribosomal small subunit biogenesis
GO_1904872Biological processregulation of telomerase RNA localization to Cajal body
GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0071034Biological processCUT catabolic process
GO_0071037Biological processnuclear polyadenylation-dependent snRNA catabolic process
GO_0071028Biological processnuclear mRNA surveillance
GO_1905746Biological processpositive regulation of mRNA cis splicing, via spliceosome
GO_0000460Biological processmaturation of 5.8S rRNA
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0006364Biological processrRNA processing
GO_0071039Biological processnuclear polyadenylation-dependent CUT catabolic process
GO_0000467Biological processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0005730Cellular componentnucleolus
GO_0000178Cellular componentexosome (RNase complex)
GO_0016020Cellular componentmembrane
GO_0032040Cellular componentsmall-subunit processome
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0101019Cellular componentnucleolar exosome (RNase complex)
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005634Cellular componentnucleus
GO_0004532Molecular functionRNA exonuclease activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0000166Molecular functionnucleotide binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0070034Molecular functiontelomerase RNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXOSC10
Protein nameExosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)
Alternative protein EXOSC10
Exosome component 10
EXOSC10 protein
SynonymsPMSCL
RRP6
PMSCL2
DescriptionFUNCTION: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination . Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage . Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation . Required for cell proliferation . Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins . .

AccessionsK7EJ37
Q96G78
Q01780
ENST00000460196.1
ENST00000304457.11 [Q01780-2]
L8E6Y6
ENST00000376936.9 [Q01780-1]