Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 28% ± 13% | |
epithelial cell | 9 studies | 35% ± 13% | |
basal cell | 8 studies | 33% ± 12% | |
macrophage | 8 studies | 28% ± 11% | |
secretory cell | 7 studies | 30% ± 18% | |
classical monocyte | 7 studies | 24% ± 8% | |
ciliated cell | 6 studies | 30% ± 11% | |
respiratory goblet cell | 5 studies | 28% ± 16% | |
glutamatergic neuron | 5 studies | 44% ± 21% | |
fibroblast | 5 studies | 32% ± 19% | |
squamous epithelial cell | 4 studies | 58% ± 21% | |
club cell | 4 studies | 26% ± 8% | |
GABAergic neuron | 4 studies | 43% ± 14% | |
endothelial cell of vascular tree | 4 studies | 26% ± 13% | |
interneuron | 4 studies | 37% ± 20% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
hematopoietic precursor cell | 3 studies | 26% ± 5% | |
extravillous trophoblast | 3 studies | 43% ± 11% | |
myeloid cell | 3 studies | 31% ± 8% | |
endothelial cell of artery | 3 studies | 15% ± 0% | |
lymphocyte | 3 studies | 22% ± 5% | |
microglial cell | 3 studies | 33% ± 17% | |
astrocyte | 3 studies | 24% ± 5% | |
CD8-positive, alpha-beta T cell | 3 studies | 17% ± 0% | |
monocyte | 3 studies | 22% ± 3% | |
transit amplifying cell | 3 studies | 26% ± 10% | |
neuron | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 13624.35 | 1444 / 1445 | 100% | 108.72 | 183 / 183 |
lung | 99% | 3192.86 | 575 / 578 | 100% | 95.26 | 1155 / 1155 |
stomach | 100% | 3033.44 | 359 / 359 | 99% | 63.24 | 284 / 286 |
bladder | 100% | 3307.76 | 21 / 21 | 99% | 64.47 | 500 / 504 |
uterus | 100% | 2504.95 | 170 / 170 | 99% | 67.72 | 454 / 459 |
intestine | 100% | 2672.62 | 966 / 966 | 99% | 65.96 | 520 / 527 |
pancreas | 99% | 2308.00 | 325 / 328 | 98% | 72.20 | 175 / 178 |
skin | 100% | 5035.45 | 1805 / 1809 | 97% | 36.43 | 456 / 472 |
breast | 100% | 3260.23 | 459 / 459 | 96% | 32.20 | 1077 / 1118 |
kidney | 100% | 2826.61 | 89 / 89 | 96% | 41.74 | 862 / 901 |
liver | 100% | 3478.31 | 226 / 226 | 96% | 27.58 | 388 / 406 |
ovary | 100% | 1663.47 | 180 / 180 | 94% | 26.48 | 406 / 430 |
thymus | 100% | 2331.65 | 651 / 653 | 94% | 22.83 | 568 / 605 |
adrenal gland | 98% | 1512.54 | 254 / 258 | 89% | 35.15 | 205 / 230 |
brain | 98% | 2000.00 | 2578 / 2642 | 82% | 14.71 | 581 / 705 |
prostate | 99% | 2127.16 | 243 / 245 | 65% | 9.64 | 324 / 502 |
adipose | 100% | 3510.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 2769.96 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 80.11 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 31.58 | 1 / 1 |
blood vessel | 100% | 3285.31 | 1332 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 6331.80 | 924 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 21.09 | 27 / 29 |
heart | 91% | 1827.54 | 784 / 861 | 0% | 0 | 0 / 0 |
muscle | 86% | 1024.37 | 693 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 59% | 10.23 | 47 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045454 | Biological process | cell redox homeostasis |
GO_0070059 | Biological process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
GO_0050873 | Biological process | brown fat cell differentiation |
GO_0022417 | Biological process | protein maturation by protein folding |
GO_0009266 | Biological process | response to temperature stimulus |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0030198 | Biological process | extracellular matrix organization |
GO_0051209 | Biological process | release of sequestered calcium ion into cytosol |
GO_0030968 | Biological process | endoplasmic reticulum unfolded protein response |
GO_0006457 | Biological process | protein folding |
GO_0036211 | Biological process | protein modification process |
GO_0034975 | Biological process | protein folding in endoplasmic reticulum |
GO_0051085 | Biological process | chaperone cofactor-dependent protein refolding |
GO_0006979 | Biological process | response to oxidative stress |
GO_0071456 | Biological process | cellular response to hypoxia |
GO_0005615 | Cellular component | extracellular space |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005796 | Cellular component | Golgi lumen |
GO_0030425 | Cellular component | dendrite |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0016972 | Molecular function | thiol oxidase activity |
GO_0071949 | Molecular function | FAD binding |
GO_0015035 | Molecular function | protein-disulfide reductase activity |
GO_0016491 | Molecular function | oxidoreductase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ERO1A |
Protein name | ERO1-like protein alpha (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) |
Synonyms | UNQ434/PRO865 ERO1L |
Description | FUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins . Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. . |
Accessions | ENST00000554019.5 ENST00000556039.5 G3V5B3 ENST00000556223.1 ENST00000554251.5 G3V2H0 G3V503 ENST00000395686.8 G3V3E6 Q96HE7 ENST00000556358.5 ENST00000629528.2 |