ERO1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0050873Biological processbrown fat cell differentiation
GO_0022417Biological processprotein maturation by protein folding
GO_0009266Biological processresponse to temperature stimulus
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0030198Biological processextracellular matrix organization
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0006457Biological processprotein folding
GO_0036211Biological processprotein modification process
GO_0034975Biological processprotein folding in endoplasmic reticulum
GO_0051085Biological processchaperone cofactor-dependent protein refolding
GO_0006979Biological processresponse to oxidative stress
GO_0071456Biological processcellular response to hypoxia
GO_0005615Cellular componentextracellular space
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005796Cellular componentGolgi lumen
GO_0030425Cellular componentdendrite
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016972Molecular functionthiol oxidase activity
GO_0071949Molecular functionFAD binding
GO_0015035Molecular functionprotein-disulfide reductase activity
GO_0016491Molecular functionoxidoreductase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERO1A
Protein nameERO1-like protein alpha (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha)
ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha)
SynonymsUNQ434/PRO865
ERO1L
DescriptionFUNCTION: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins . Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. .

AccessionsENST00000554019.5
ENST00000556039.5
G3V5B3
ENST00000556223.1
ENST00000554251.5
G3V2H0
G3V503
ENST00000395686.8
G3V3E6
Q96HE7
ENST00000556358.5
ENST00000629528.2