Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| goblet cell | 9 studies | 39% ± 21% | |
| respiratory goblet cell | 7 studies | 37% ± 16% | |
| mucus secreting cell | 4 studies | 24% ± 5% | |
| ciliated cell | 3 studies | 23% ± 6% | |
| secretory cell | 3 studies | 36% ± 12% | |
| epithelial cell | 3 studies | 26% ± 7% | |
| basal cell | 3 studies | 20% ± 2% |
Insufficient scRNA-seq data for expression of ERN2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 84% | 3974.16 | 303 / 359 | 89% | 43.33 | 254 / 286 |
| intestine | 74% | 3457.72 | 716 / 966 | 95% | 59.67 | 501 / 527 |
| pancreas | 59% | 128.13 | 193 / 328 | 84% | 62.06 | 149 / 178 |
| bladder | 86% | 938.05 | 18 / 21 | 50% | 20.55 | 251 / 504 |
| adrenal gland | 97% | 103.19 | 250 / 258 | 1% | 0.13 | 3 / 230 |
| prostate | 87% | 806.67 | 214 / 245 | 7% | 0.90 | 37 / 502 |
| lung | 59% | 201.15 | 340 / 578 | 34% | 13.83 | 388 / 1155 |
| esophagus | 15% | 77.09 | 212 / 1445 | 48% | 33.12 | 87 / 183 |
| skin | 43% | 34.92 | 770 / 1809 | 0% | 0 | 0 / 472 |
| uterus | 10% | 130.55 | 17 / 170 | 28% | 15.54 | 130 / 459 |
| breast | 16% | 26.10 | 75 / 459 | 1% | 0.17 | 11 / 1118 |
| liver | 12% | 6.96 | 26 / 226 | 1% | 0.80 | 6 / 406 |
| adipose | 11% | 7.14 | 128 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 9% | 1.06 | 4 / 45 |
| kidney | 3% | 1.10 | 3 / 89 | 0% | 0.07 | 2 / 901 |
| ovary | 1% | 0.24 | 1 / 180 | 2% | 0.26 | 7 / 430 |
| thymus | 2% | 1.46 | 14 / 653 | 0% | 0 | 0 / 605 |
| blood vessel | 1% | 0.62 | 17 / 1335 | 0% | 0 | 0 / 0 |
| brain | 1% | 0.35 | 28 / 2642 | 0% | 0 | 0 / 705 |
| muscle | 1% | 0.43 | 5 / 803 | 0% | 0 | 0 / 0 |
| heart | 1% | 0.19 | 5 / 861 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0.14 | 1 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 2.24 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0070059 | Biological process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| GO_0006397 | Biological process | mRNA processing |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_0030263 | Biological process | apoptotic chromosome condensation |
| GO_0016075 | Biological process | rRNA catabolic process |
| GO_0036498 | Biological process | IRE1-mediated unfolded protein response |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_1990604 | Cellular component | IRE1-TRAF2-ASK1 complex |
| GO_0044322 | Cellular component | endoplasmic reticulum quality control compartment |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0004521 | Molecular function | RNA endonuclease activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004519 | Molecular function | endonuclease activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0051082 | Molecular function | unfolded protein binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | ERN2 |
| Protein name | Endoplasmic reticulum to nucleus signaling 2 non-specific serine/threonine protein kinase (EC 2.7.11.1) Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] |
| Synonyms | IRE2 |
| Description | FUNCTION: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. . |
| Accessions | A5YM46 H3BSU1 ENST00000562562.1 H3BTW8 ENST00000457008.6 E7ETG2 H3BUU2 Q76MJ5 ENST00000569903.1 A5YM65 ENST00000562458.2 ENST00000256797.9 |
