ERLIN2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ERLIN2 at tissue level.

III. Associated gene sets

GO_0008203Biological processcholesterol metabolic process
GO_0032933Biological processSREBP signaling pathway
GO_0045540Biological processregulation of cholesterol biosynthetic process
GO_0036503Biological processERAD pathway
GO_0045717Biological processnegative regulation of fatty acid biosynthetic process
GO_0045541Biological processnegative regulation of cholesterol biosynthetic process
GO_0045121Cellular componentmembrane raft
GO_0032991Cellular componentprotein-containing complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015485Molecular functioncholesterol binding
GO_0005515Molecular functionprotein binding
GO_0031625Molecular functionubiquitin protein ligase binding

IV. Literature review

[source]
Gene nameERLIN2
Protein nameErlin (SPFH domain-containing protein) (Endoplasmic reticulum lipid raft-associated protein) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein)
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)
SynonymsC8orf2
SPFH2
UNQ2441/PRO5003/PRO9924
DescriptionFUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 . Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex . Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex . .

FUNCTION: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. .

FUNCTION: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. .

AccessionsENST00000648919.1 [O94905-2]
E5RJ09
ENST00000523107.5 [O94905-3]
ENST00000521644.5
E5RHW4
ENST00000519638.3 [O94905-1]
ENST00000335171.10 [O94905-2]
ENST00000518586.5 [O94905-3]
O94905
ENST00000523887.5 [O94905-3]
ENST00000518526.5