ERLIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008203Biological processcholesterol metabolic process
GO_0032933Biological processSREBP signaling pathway
GO_0045540Biological processregulation of cholesterol biosynthetic process
GO_0036503Biological processERAD pathway
GO_0045717Biological processnegative regulation of fatty acid biosynthetic process
GO_0045541Biological processnegative regulation of cholesterol biosynthetic process
GO_0045121Cellular componentmembrane raft
GO_0032991Cellular componentprotein-containing complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015485Molecular functioncholesterol binding
GO_0005515Molecular functionprotein binding
GO_0031625Molecular functionubiquitin protein ligase binding

IV. Literature review

[source]
Gene nameERLIN1
Protein nameErlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1)
Erlin (SPFH domain-containing protein) (Endoplasmic reticulum lipid raft-associated protein) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein)
SynonymsC10orf69
KEO4
SPFH1
KE04
DescriptionFUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway . Binds cholesterol and may promote ER retention of the SCAP-SREBF complex . .; FUNCTION: (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. .

FUNCTION: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. .

AccessionsO75477
ENST00000407654.7
B0QZ43
ENST00000421367.7
ENST00000370408.2