ERCC6L report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ERCC6L at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ERCC6L at tissue level.

III. Associated gene sets

GO_0051301Biological processcell division
GO_0006338Biological processchromatin remodeling
GO_0000776Cellular componentkinetochore
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0003677Molecular functionDNA binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0004386Molecular functionhelicase activity
GO_0015616Molecular functionDNA translocase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameERCC6L
Protein nameDNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)
ERCC excision repair 6 like, spindle assembly checkpoint helicase (FLJ20105 protein, isoform CRA_a)
SynonymsPICH
hCG_1642107
FLJ20105
DescriptionFUNCTION: DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase . Functions as ATP-dependent DNA translocase . Can promote Holliday junction branch migration (in vitro) . .

AccessionsENST00000373657.2
ENST00000334463.4
B5MDQ0
Q2NKX8