ERC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048167Biological processregulation of synaptic plasticity
GO_0150037Biological processregulation of calcium-dependent activation of synaptic vesicle fusion
GO_0016082Biological processsynaptic vesicle priming
GO_0007274Biological processneuromuscular synaptic transmission
GO_0099509Biological processregulation of presynaptic cytosolic calcium ion concentration
GO_0048790Biological processmaintenance of presynaptic active zone structure
GO_0098978Cellular componentglutamatergic synapse
GO_0098982Cellular componentGABA-ergic synapse
GO_0048786Cellular componentpresynaptic active zone
GO_0048788Cellular componentcytoskeleton of presynaptic active zone
GO_0030426Cellular componentgrowth cone
GO_0042734Cellular componentpresynaptic membrane
GO_0098882Molecular functionstructural constituent of presynaptic active zone
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERC2
Protein nameERC protein 2
ELKS/RAB6-interacting/CAST family member 2
SynonymsKIAA0378
DescriptionFUNCTION: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.

AccessionsENST00000288221.11
ENST00000460849.5
ENST00000492584.3
O15083
H7C4G9