I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 22% ± 5% | |
| ciliated cell | 3 studies | 24% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 22% ± 5% | |
| ciliated cell | 3 studies | 24% ± 3% |
Insufficient scRNA-seq data for expression of EPPK1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 93% | 860.11 | 896 / 966 | 95% | 10.53 | 501 / 527 |
| esophagus | 90% | 1008.16 | 1305 / 1445 | 97% | 23.12 | 178 / 183 |
| stomach | 92% | 557.28 | 330 / 359 | 94% | 13.69 | 269 / 286 |
| bladder | 90% | 630.86 | 19 / 21 | 78% | 6.57 | 391 / 504 |
| lung | 74% | 317.82 | 427 / 578 | 79% | 7.17 | 910 / 1155 |
| breast | 54% | 353.99 | 248 / 459 | 91% | 11.79 | 1012 / 1118 |
| uterus | 59% | 440.15 | 101 / 170 | 78% | 7.74 | 358 / 459 |
| prostate | 84% | 488.40 | 205 / 245 | 50% | 3.30 | 253 / 502 |
| kidney | 80% | 299.52 | 71 / 89 | 38% | 1.61 | 345 / 901 |
| pancreas | 40% | 96.53 | 130 / 328 | 74% | 4.64 | 131 / 178 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.54 | 1 / 1 |
| spleen | 93% | 395.99 | 225 / 241 | 0% | 0 | 0 / 0 |
| ovary | 4% | 8.09 | 7 / 180 | 89% | 12.04 | 384 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 10.22 | 40 / 45 |
| skin | 72% | 3173.38 | 1303 / 1809 | 6% | 0.30 | 26 / 472 |
| thymus | 23% | 47.64 | 153 / 653 | 51% | 2.60 | 309 / 605 |
| blood vessel | 43% | 154.76 | 572 / 1335 | 0% | 0 | 0 / 0 |
| liver | 8% | 21.48 | 17 / 226 | 33% | 2.27 | 133 / 406 |
| brain | 14% | 41.68 | 378 / 2642 | 0% | 0.02 | 2 / 705 |
| adipose | 9% | 21.50 | 111 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 1% | 1.77 | 2 / 258 | 1% | 0.02 | 2 / 230 |
| peripheral blood | 1% | 1.33 | 6 / 929 | 0% | 0 | 0 / 0 |
| heart | 1% | 1.74 | 5 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 2.30 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0061045 | Biological process | negative regulation of wound healing |
| GO_0051548 | Biological process | negative regulation of keratinocyte migration |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0010839 | Biological process | negative regulation of keratinocyte proliferation |
| GO_0042060 | Biological process | wound healing |
| GO_0045109 | Biological process | intermediate filament organization |
| GO_1905041 | Biological process | regulation of epithelium regeneration |
| GO_0045110 | Biological process | intermediate filament bundle assembly |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0016020 | Cellular component | membrane |
| GO_0005882 | Cellular component | intermediate filament |
| GO_0030056 | Cellular component | hemidesmosome |
| GO_0045111 | Cellular component | intermediate filament cytoskeleton |
| GO_0071944 | Cellular component | cell periphery |
| GO_0045095 | Cellular component | keratin filament |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0042995 | Cellular component | cell projection |
| GO_0030054 | Cellular component | cell junction |
| GO_0016327 | Cellular component | apicolateral plasma membrane |
| GO_0097356 | Cellular component | perinucleolar compartment |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005198 | Molecular function | structural molecule activity |
| GO_0019215 | Molecular function | intermediate filament binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_1990254 | Molecular function | keratin filament binding |
| Gene name | EPPK1 |
| Protein name | Epiplakin 1 Epiplakin (450 kDa epidermal antigen) |
| Synonyms | EPIPL |
| Description | FUNCTION: Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress . In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture . However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity). . |
| Accessions | ENST00000568225.2 ENST00000615648.2 P58107 A0A075B730 |
