EPHA8 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of EPHA8 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	98%	179.64	323 / 328	11%	0.30	20 / 178
adrenal gland	44%	145.76	114 / 258	63%	14.46	144 / 230
spleen	100%	695.37	241 / 241	0%	0	0 / 0
brain	92%	157.55	2437 / 2642	6%	0.32	42 / 705
skin	19%	9.94	339 / 1809	10%	0.39	49 / 472
eye	0%	0	0 / 0	26%	0.65	21 / 80
prostate	10%	4.20	24 / 245	14%	0.25	70 / 502
breast	3%	1.13	14 / 459	19%	0.74	212 / 1118
blood vessel	14%	12.22	190 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	11%	0.32	5 / 45
esophagus	3%	0.91	44 / 1445	7%	0.12	12 / 183
uterus	1%	0.34	2 / 170	7%	0.24	34 / 459
ovary	3%	1.13	6 / 180	5%	0.11	20 / 430
stomach	1%	0.15	2 / 359	6%	0.27	18 / 286
kidney	4%	6.47	4 / 89	1%	0.02	8 / 901
lung	0%	0.05	1 / 578	5%	0.14	55 / 1155
bladder	0%	0	0 / 21	5%	0.22	24 / 504
intestine	1%	0.28	9 / 966	4%	0.16	20 / 527
thymus	4%	1.36	26 / 653	1%	0.01	4 / 605
muscle	2%	0.78	19 / 803	0%	0	0 / 0
adipose	1%	0.46	11 / 1204	0%	0	0 / 0
heart	0%	0.10	3 / 861	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0.01	1 / 406
peripheral blood	0%	0.05	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0016322	Biological process	neuron remodeling
GO_0071372	Biological process	cellular response to follicle-stimulating hormone stimulus
GO_0031175	Biological process	neuron projection development
GO_0007155	Biological process	cell adhesion
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0006929	Biological process	substrate-dependent cell migration
GO_0033628	Biological process	regulation of cell adhesion mediated by integrin
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006468	Biological process	protein phosphorylation
GO_0030155	Biological process	regulation of cell adhesion
GO_0007411	Biological process	axon guidance
GO_0005886	Cellular component	plasma membrane
GO_0031901	Cellular component	early endosome membrane
GO_0043005	Cellular component	neuron projection
GO_0030425	Cellular component	dendrite
GO_0005004	Molecular function	GPI-linked ephrin receptor activity
GO_0005003	Molecular function	ephrin receptor activity
GO_0005005	Molecular function	transmembrane-ephrin receptor activity
GO_0019838	Molecular function	growth factor binding
GO_0005524	Molecular function	ATP binding

Gene name	EPHA8
Protein name	Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)
Synonyms	HEK3 KIAA1459 EEK
Description	FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). .
Accessions	ENST00000166244.8 [P29322-1] P29322 ENST00000374644.8 [P29322-2]

EPHA8 report