Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 12 studies | 38% ± 18% | |
| GABAergic neuron | 9 studies | 43% ± 20% | |
| neuron | 6 studies | 28% ± 12% | |
| interneuron | 6 studies | 41% ± 24% | |
| granule cell | 4 studies | 39% ± 22% | |
| GABAergic interneuron | 3 studies | 48% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 10 studies | 33% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 95% | 1912.74 | 233 / 245 | 92% | 8.80 | 461 / 502 |
| kidney | 78% | 505.06 | 69 / 89 | 81% | 20.95 | 730 / 901 |
| bladder | 95% | 2635.57 | 20 / 21 | 22% | 1.65 | 109 / 504 |
| brain | 79% | 1002.87 | 2090 / 2642 | 34% | 1.92 | 243 / 705 |
| spleen | 98% | 842.32 | 236 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 62% | 6786.42 | 893 / 1445 | 28% | 5.01 | 52 / 183 |
| intestine | 79% | 5332.58 | 765 / 966 | 7% | 0.61 | 39 / 527 |
| stomach | 50% | 3095.08 | 178 / 359 | 16% | 1.71 | 47 / 286 |
| heart | 61% | 459.50 | 529 / 861 | 0% | 0 | 0 / 0 |
| uterus | 16% | 78.99 | 28 / 170 | 22% | 2.45 | 102 / 459 |
| lung | 4% | 13.76 | 22 / 578 | 28% | 3.28 | 322 / 1155 |
| ovary | 21% | 90.77 | 38 / 180 | 10% | 0.56 | 45 / 430 |
| breast | 7% | 33.22 | 31 / 459 | 12% | 1.08 | 129 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 1.32 | 8 / 45 |
| pancreas | 0% | 0 | 0 / 328 | 12% | 1.26 | 22 / 178 |
| adrenal gland | 1% | 6.95 | 2 / 258 | 10% | 0.60 | 22 / 230 |
| thymus | 1% | 11.47 | 6 / 653 | 6% | 0.49 | 36 / 605 |
| skin | 3% | 10.30 | 48 / 1809 | 2% | 0.35 | 9 / 472 |
| blood vessel | 4% | 15.55 | 48 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 2% | 9.44 | 29 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 2% | 0.25 | 8 / 406 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0048013 | Biological process | ephrin receptor signaling pathway |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
| GO_0022407 | Biological process | regulation of cell-cell adhesion |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0050730 | Biological process | regulation of peptidyl-tyrosine phosphorylation |
| GO_0051402 | Biological process | neuron apoptotic process |
| GO_0043281 | Biological process | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO_0051964 | Biological process | negative regulation of synapse assembly |
| GO_0007420 | Biological process | brain development |
| GO_0072178 | Biological process | nephric duct morphogenesis |
| GO_0016310 | Biological process | phosphorylation |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0031952 | Biological process | regulation of protein autophosphorylation |
| GO_0031290 | Biological process | retinal ganglion cell axon guidance |
| GO_0048755 | Biological process | branching morphogenesis of a nerve |
| GO_0048671 | Biological process | negative regulation of collateral sprouting |
| GO_0007411 | Biological process | axon guidance |
| GO_0099175 | Biological process | regulation of postsynapse organization |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005004 | Molecular function | GPI-linked ephrin receptor activity |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0008046 | Molecular function | axon guidance receptor activity |
| GO_0005005 | Molecular function | transmembrane-ephrin receptor activity |
| GO_0019838 | Molecular function | growth factor binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0045499 | Molecular function | chemorepellent activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EPHA7 |
| Protein name | EPH receptor A7 Alternative protein EPHA7 receptor protein-tyrosine kinase (EC 2.7.10.1) Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) |
| Synonyms | HEK11 hCG_32399 EHK3 |
| Description | FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. . |
| Accessions | ENST00000679565.1 A0A7P0T9G1 ENST00000369303.9 [Q15375-1] A0A7P0TBL4 A0A7P0T9V9 ENST00000680953.1 L8EAA4 A0A7P0TA58 ENST00000369297.1 [Q15375-3] ENST00000680224.1 [Q15375-4] A0A7P0T9L5 Q15375 A0A7P0TB85 ENST00000681130.1 ENST00000681532.1 ENST00000680082.1 ENST00000680190.1 |
