EPG5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034162Biological processtoll-like receptor 9 signaling pathway
GO_0097352Biological processautophagosome maturation
GO_0008333Biological processendosome to lysosome transport
GO_0032456Biological processendocytic recycling
GO_1990786Biological processcellular response to dsDNA
GO_0006862Biological processnucleotide transport
GO_0005764Cellular componentlysosome
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEPG5
Protein nameEctopic P-granules 5 autophagy tethering factor
Ectopic P granules protein 5 homolog
SynonymsKIAA1632
DescriptionFUNCTION: Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located . .

AccessionsA0A8Q3SIJ4
ENST00000590884.6
ENST00000587884.2
Q9HCE0
A0A8Q3SIJ2
ENST00000696484.1
ENST00000696489.1
K7EPN4
ENST00000587262.1
A0A8Q3WLI3
ENST00000696482.1
ENST00000696483.1
ENST00000696490.1
K7EM87
K7ENK5
ENST00000282041.11 [Q9HCE0-1]
A0A8Q3SJD2
ENST00000696485.1
ENST00000592272.6
A0A8Q3SIP5
A0A8Q3SIU6