EP400 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_2000779Biological processregulation of double-strand break repair
GO_0006338Biological processchromatin remodeling
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0051726Biological processregulation of cell cycle
GO_0000812Cellular componentSwr1 complex
GO_0000786Cellular componentnucleosome
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0003677Molecular functionDNA binding
GO_0004386Molecular functionhelicase activity
GO_0003682Molecular functionchromatin binding
GO_0016787Molecular functionhydrolase activity
GO_1990405Molecular functionprotein antigen binding
GO_0005524Molecular functionATP binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEP400
Protein nameEP400 protein
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
E1A binding protein p400
SynonymsCAGH32
KIAA1818
KIAA1498
TNRC12
DescriptionFUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. .

AccessionsQ96L91
ENST00000333577.8
ENST00000332482.8
A0A0A0MR80
ENST00000703283.1
A0A0A0MR70
A0A8V8TRJ5
ENST00000330386.7
A0A0A0MR72
ENST00000389561.7 [Q96L91-2]
A7E2D7