Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 29% ± 15% | |
astrocyte | 11 studies | 30% ± 13% | |
ciliated cell | 9 studies | 27% ± 7% | |
microglial cell | 9 studies | 28% ± 11% | |
oligodendrocyte precursor cell | 9 studies | 31% ± 13% | |
glutamatergic neuron | 8 studies | 40% ± 25% | |
oligodendrocyte | 8 studies | 28% ± 9% | |
GABAergic neuron | 7 studies | 39% ± 20% | |
interneuron | 6 studies | 41% ± 21% | |
macrophage | 6 studies | 30% ± 9% | |
neuron | 5 studies | 30% ± 11% | |
epithelial cell | 5 studies | 31% ± 12% | |
adipocyte | 5 studies | 20% ± 3% | |
fibroblast | 5 studies | 22% ± 7% | |
lymphocyte | 4 studies | 22% ± 6% | |
dendritic cell | 4 studies | 20% ± 5% | |
endothelial cell of lymphatic vessel | 4 studies | 24% ± 7% | |
smooth muscle cell | 4 studies | 18% ± 2% | |
plasmacytoid dendritic cell | 4 studies | 21% ± 5% | |
GABAergic interneuron | 3 studies | 29% ± 14% | |
granule cell | 3 studies | 28% ± 5% | |
myeloid cell | 3 studies | 22% ± 3% | |
basal cell | 3 studies | 27% ± 14% | |
monocyte | 3 studies | 18% ± 2% | |
pericyte | 3 studies | 22% ± 7% | |
goblet cell | 3 studies | 32% ± 19% | |
transit amplifying cell | 3 studies | 30% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4608.76 | 1445 / 1445 | 100% | 21.41 | 183 / 183 |
skin | 100% | 6014.05 | 1809 / 1809 | 100% | 14.23 | 470 / 472 |
breast | 100% | 5122.00 | 459 / 459 | 100% | 14.31 | 1113 / 1118 |
stomach | 100% | 3584.33 | 359 / 359 | 99% | 14.66 | 284 / 286 |
intestine | 100% | 5112.76 | 966 / 966 | 99% | 13.00 | 523 / 527 |
thymus | 100% | 6219.92 | 653 / 653 | 99% | 12.40 | 600 / 605 |
bladder | 100% | 5088.10 | 21 / 21 | 99% | 11.24 | 498 / 504 |
uterus | 100% | 6645.30 | 170 / 170 | 99% | 11.28 | 453 / 459 |
brain | 99% | 4014.16 | 2621 / 2642 | 99% | 15.65 | 698 / 705 |
lung | 100% | 4794.95 | 578 / 578 | 98% | 13.37 | 1131 / 1155 |
pancreas | 100% | 2562.29 | 328 / 328 | 98% | 9.49 | 174 / 178 |
prostate | 100% | 5145.12 | 245 / 245 | 97% | 10.41 | 487 / 502 |
kidney | 100% | 3475.94 | 89 / 89 | 95% | 9.00 | 860 / 901 |
adrenal gland | 100% | 4907.74 | 258 / 258 | 95% | 11.08 | 219 / 230 |
ovary | 100% | 7317.22 | 180 / 180 | 95% | 11.60 | 407 / 430 |
liver | 100% | 2057.86 | 226 / 226 | 69% | 4.41 | 281 / 406 |
adipose | 100% | 4660.90 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4433.22 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.62 | 29 / 29 |
muscle | 100% | 3567.65 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5474.46 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.64 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.79 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 10.00 | 79 / 80 |
heart | 98% | 2400.82 | 847 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 69% | 2272.73 | 644 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006281 | Biological process | DNA repair |
GO_2000779 | Biological process | regulation of double-strand break repair |
GO_0006338 | Biological process | chromatin remodeling |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_1905168 | Biological process | positive regulation of double-strand break repair via homologous recombination |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0000812 | Cellular component | Swr1 complex |
GO_0000786 | Cellular component | nucleosome |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0035267 | Cellular component | NuA4 histone acetyltransferase complex |
GO_0003677 | Molecular function | DNA binding |
GO_0004386 | Molecular function | helicase activity |
GO_0003682 | Molecular function | chromatin binding |
GO_0016787 | Molecular function | hydrolase activity |
GO_1990405 | Molecular function | protein antigen binding |
GO_0005524 | Molecular function | ATP binding |
GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
GO_0005515 | Molecular function | protein binding |
Gene name | EP400 |
Protein name | EP400 protein E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) E1A binding protein p400 |
Synonyms | CAGH32 KIAA1818 KIAA1498 TNRC12 |
Description | FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. . |
Accessions | Q96L91 ENST00000333577.8 ENST00000332482.8 A0A0A0MR80 ENST00000703283.1 A0A0A0MR70 A0A8V8TRJ5 ENST00000330386.7 A0A0A0MR72 ENST00000389561.7 [Q96L91-2] A7E2D7 |