ENTPD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070527Biological processplatelet aggregation
GO_0007155Biological processcell adhesion
GO_0007596Biological processblood coagulation
GO_0009134Biological processnucleoside diphosphate catabolic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005901Cellular componentcaveola
GO_0017111Molecular functionribonucleoside triphosphate phosphatase activity
GO_0043273Molecular functionCTPase activity
GO_0036384Molecular functionCDP phosphatase activity
GO_0103023Molecular functionITPase activity
GO_0004050Molecular functionapyrase activity
GO_0005524Molecular functionATP binding
GO_1990003Molecular functionIDP phosphatase activity
GO_0004382Molecular functionGDP phosphatase activity
GO_0045134Molecular functionUDP phosphatase activity
GO_0043262Molecular functionADP phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0017110Molecular functionnucleoside diphosphate phosphatase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameENTPD1
Protein nameEctonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39)
Alternative protein ENTPD1
Ectonucleoside triphosphate diphosphohydrolase 1
SynonymsCD39
DescriptionFUNCTION: Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow . .

AccessionsENST00000371205.5 [P49961-1]
A0A0U1RR44
ENST00000639992.1
P49961
ENST00000483213.6
L8E7N4
ENST00000543964.6 [P49961-5]
A0A1W2PQK8
A0A0U1RQZ5
ENST00000635076.1
ENST00000371207.8 [P49961-6]
ENST00000453258.6 [P49961-2]