Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 32 studies | 25% ± 8% | |
| macrophage | 21 studies | 28% ± 11% | |
| conventional dendritic cell | 20 studies | 25% ± 9% | |
| microglial cell | 14 studies | 45% ± 20% | |
| smooth muscle cell | 13 studies | 21% ± 5% | |
| monocyte | 12 studies | 26% ± 11% | |
| vein endothelial cell | 12 studies | 37% ± 15% | |
| classical monocyte | 11 studies | 25% ± 10% | |
| dendritic cell | 10 studies | 33% ± 11% | |
| endothelial cell of artery | 10 studies | 27% ± 7% | |
| myeloid cell | 10 studies | 27% ± 9% | |
| regulatory T cell | 8 studies | 25% ± 5% | |
| B cell | 7 studies | 17% ± 1% | |
| endothelial cell of vascular tree | 7 studies | 28% ± 12% | |
| mononuclear phagocyte | 6 studies | 30% ± 12% | |
| capillary endothelial cell | 6 studies | 23% ± 7% | |
| plasma cell | 5 studies | 34% ± 12% | |
| astrocyte | 5 studies | 42% ± 13% | |
| gamma-delta T cell | 4 studies | 34% ± 10% | |
| memory B cell | 4 studies | 20% ± 3% | |
| neutrophil | 4 studies | 21% ± 8% | |
| plasmablast | 3 studies | 47% ± 23% | |
| myofibroblast cell | 3 studies | 23% ± 5% | |
| non-classical monocyte | 3 studies | 22% ± 3% | |
| alveolar macrophage | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2151.25 | 652 / 653 | 100% | 35.88 | 605 / 605 |
| brain | 99% | 1374.06 | 2607 / 2642 | 100% | 9.44 | 705 / 705 |
| breast | 99% | 2017.51 | 455 / 459 | 99% | 9.24 | 1111 / 1118 |
| esophagus | 99% | 2652.75 | 1437 / 1445 | 99% | 7.93 | 181 / 183 |
| lung | 100% | 3273.44 | 578 / 578 | 98% | 7.52 | 1132 / 1155 |
| uterus | 100% | 4613.55 | 170 / 170 | 97% | 6.35 | 443 / 459 |
| prostate | 100% | 2542.36 | 244 / 245 | 97% | 4.96 | 485 / 502 |
| intestine | 100% | 2880.90 | 962 / 966 | 97% | 6.51 | 509 / 527 |
| adrenal gland | 100% | 1921.45 | 258 / 258 | 95% | 5.89 | 218 / 230 |
| kidney | 99% | 1467.54 | 88 / 89 | 95% | 10.70 | 854 / 901 |
| bladder | 100% | 4055.71 | 21 / 21 | 93% | 6.36 | 467 / 504 |
| stomach | 91% | 1400.05 | 326 / 359 | 97% | 7.85 | 277 / 286 |
| ovary | 92% | 1211.29 | 166 / 180 | 80% | 3.00 | 345 / 430 |
| skin | 76% | 967.27 | 1381 / 1809 | 93% | 7.14 | 438 / 472 |
| pancreas | 21% | 154.74 | 70 / 328 | 98% | 9.73 | 175 / 178 |
| blood vessel | 100% | 6226.62 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 16.85 | 29 / 29 |
| spleen | 100% | 4100.74 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.92 | 1 / 1 |
| adipose | 99% | 2121.73 | 1195 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 8981.35 | 921 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 6.55 | 43 / 45 |
| liver | 24% | 156.23 | 54 / 226 | 60% | 2.51 | 245 / 406 |
| heart | 81% | 815.74 | 699 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 78% | 6.70 | 62 / 80 |
| muscle | 42% | 314.38 | 338 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0070527 | Biological process | platelet aggregation |
| GO_0007155 | Biological process | cell adhesion |
| GO_0007596 | Biological process | blood coagulation |
| GO_0009134 | Biological process | nucleoside diphosphate catabolic process |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005901 | Cellular component | caveola |
| GO_0017111 | Molecular function | ribonucleoside triphosphate phosphatase activity |
| GO_0043273 | Molecular function | CTPase activity |
| GO_0036384 | Molecular function | CDP phosphatase activity |
| GO_0103023 | Molecular function | ITPase activity |
| GO_0004050 | Molecular function | apyrase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_1990003 | Molecular function | IDP phosphatase activity |
| GO_0004382 | Molecular function | GDP phosphatase activity |
| GO_0045134 | Molecular function | UDP phosphatase activity |
| GO_0043262 | Molecular function | ADP phosphatase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0017110 | Molecular function | nucleoside diphosphate phosphatase activity |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | ENTPD1 |
| Protein name | Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39) Alternative protein ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1 |
| Synonyms | CD39 |
| Description | FUNCTION: Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow . . |
| Accessions | ENST00000371205.5 [P49961-1] A0A0U1RR44 ENST00000639992.1 P49961 ENST00000483213.6 L8E7N4 ENST00000543964.6 [P49961-5] A0A1W2PQK8 A0A0U1RQZ5 ENST00000635076.1 ENST00000371207.8 [P49961-6] ENST00000453258.6 [P49961-2] |