Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 12 studies | 30% ± 13% | |
| fibroblast | 11 studies | 25% ± 10% | |
| astrocyte | 11 studies | 30% ± 13% | |
| endothelial cell | 10 studies | 24% ± 6% | |
| pericyte | 9 studies | 21% ± 4% | |
| ciliated cell | 9 studies | 29% ± 7% | |
| epithelial cell | 7 studies | 32% ± 13% | |
| basal cell | 6 studies | 30% ± 11% | |
| smooth muscle cell | 4 studies | 21% ± 3% | |
| club cell | 4 studies | 24% ± 2% | |
| Mueller cell | 4 studies | 19% ± 2% | |
| macrophage | 4 studies | 20% ± 1% | |
| oligodendrocyte precursor cell | 4 studies | 32% ± 11% | |
| retinal rod cell | 3 studies | 17% ± 1% | |
| myofibroblast cell | 3 studies | 17% ± 1% | |
| type I pneumocyte | 3 studies | 20% ± 4% | |
| GABAergic neuron | 3 studies | 40% ± 2% | |
| glutamatergic neuron | 3 studies | 49% ± 3% | |
| dendritic cell | 3 studies | 20% ± 5% | |
| ependymal cell | 3 studies | 31% ± 13% | |
| goblet cell | 3 studies | 19% ± 3% | |
| adipocyte | 3 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 2255.74 | 2642 / 2642 | 100% | 30.40 | 705 / 705 |
| esophagus | 100% | 2110.23 | 1445 / 1445 | 100% | 20.64 | 183 / 183 |
| lung | 100% | 2094.86 | 578 / 578 | 100% | 26.03 | 1155 / 1155 |
| pancreas | 100% | 1276.24 | 328 / 328 | 100% | 20.71 | 178 / 178 |
| breast | 100% | 2131.33 | 459 / 459 | 100% | 30.02 | 1117 / 1118 |
| prostate | 100% | 1613.40 | 245 / 245 | 100% | 21.58 | 501 / 502 |
| ovary | 100% | 1612.06 | 180 / 180 | 100% | 15.80 | 429 / 430 |
| liver | 100% | 1034.54 | 226 / 226 | 100% | 20.02 | 405 / 406 |
| uterus | 100% | 1666.03 | 170 / 170 | 100% | 23.21 | 457 / 459 |
| thymus | 100% | 1870.97 | 653 / 653 | 100% | 21.42 | 602 / 605 |
| kidney | 100% | 1968.91 | 89 / 89 | 99% | 21.68 | 895 / 901 |
| bladder | 100% | 1889.62 | 21 / 21 | 99% | 20.80 | 499 / 504 |
| stomach | 100% | 1560.38 | 359 / 359 | 99% | 19.45 | 283 / 286 |
| adrenal gland | 100% | 2073.12 | 258 / 258 | 98% | 23.67 | 225 / 230 |
| intestine | 100% | 2043.67 | 966 / 966 | 98% | 19.61 | 515 / 527 |
| skin | 100% | 1718.01 | 1809 / 1809 | 97% | 24.36 | 459 / 472 |
| blood vessel | 100% | 2383.93 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 14.53 | 29 / 29 |
| muscle | 100% | 1821.73 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1490.44 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 21.25 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.00 | 1 / 1 |
| adipose | 100% | 2275.01 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 1708.79 | 845 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 94% | 23.87 | 75 / 80 |
| peripheral blood | 58% | 798.83 | 542 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071816 | Biological process | tail-anchored membrane protein insertion into ER membrane |
| GO_0045050 | Biological process | protein insertion into ER membrane by stop-transfer membrane-anchor sequence |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0072546 | Cellular component | EMC complex |
| GO_0042406 | Cellular component | extrinsic component of endoplasmic reticulum membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0032977 | Molecular function | membrane insertase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EMC2 |
| Protein name | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) ER membrane protein complex subunit 2 |
| Synonyms | TTC35 KIAA0103 |
| Description | FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). . FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. . FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. . |
| Accessions | ENST00000220853.8 Q15006 ENST00000519642.1 E5RGJ2 H0YAS9 ENST00000524143.5 |