ELOVL7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0034626Biological processfatty acid elongation, polyunsaturated fatty acid
GO_0019367Biological processfatty acid elongation, saturated fatty acid
GO_0034625Biological processfatty acid elongation, monounsaturated fatty acid
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0006636Biological processunsaturated fatty acid biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005515Molecular functionprotein binding
GO_0009922Molecular functionfatty acid elongase activity

IV. Literature review

[source]
Gene nameELOVL7
Protein nameVery long chain fatty acid elongase 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Elongation of very long chain fatty acids protein 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7)
ELOVL fatty acid elongase 7
Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase)
Synonyms
DescriptionFUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

AccessionsENST00000425382.5
D6RBM2
D6RBR5
ENST00000511799.5
D6RE10
ENST00000508821.6
ENST00000505959.5
ENST00000514809.1
ENST00000507047.5
D6RHD0
ENST00000504455.5
A1L3X0