ELOVL6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0030148Biological processsphingolipid biosynthetic process
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0034626Biological processfatty acid elongation, polyunsaturated fatty acid
GO_0019367Biological processfatty acid elongation, saturated fatty acid
GO_0034625Biological processfatty acid elongation, monounsaturated fatty acid
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0006636Biological processunsaturated fatty acid biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0009923Cellular componentfatty acid elongase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005515Molecular functionprotein binding
GO_0009922Molecular functionfatty acid elongase activity

IV. Literature review

[source]
Gene nameELOVL6
Protein nameVery long chain fatty acid elongase 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Elongation of very long chain fatty acids protein 6) (Fatty acid elongase 2) (hELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6)
Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase)
SynonymsFACE
LCE
DescriptionFUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

AccessionsENST00000394607.7
Q9H5J4
D6RCU0
ENST00000302274.8
ENST00000514184.5
D6RBP4
ENST00000506625.5
D6RHI2
ENST00000503885.1