ELOVL2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ELOVL2 at tissue level.

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0034626Biological processfatty acid elongation, polyunsaturated fatty acid
GO_0036109Biological processalpha-linolenic acid metabolic process
GO_0019367Biological processfatty acid elongation, saturated fatty acid
GO_0043651Biological processlinoleic acid metabolic process
GO_0034625Biological processfatty acid elongation, monounsaturated fatty acid
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0006636Biological processunsaturated fatty acid biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005515Molecular functionprotein binding
GO_0009922Molecular functionfatty acid elongase activity

IV. Literature review

[source]
Gene nameELOVL2
Protein nameVery long chain fatty acid elongase 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Elongation of very long chain fatty acids protein 2) (Very long chain 3-ketoacyl-CoA synthase 2) (Very long chain 3-oxoacyl-CoA synthase 2)
SynonymsELG3
SSC2
DescriptionFUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

AccessionsQ9NXB9
ENST00000354666.4