EIF3CL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EIF3CL at tissue level.

III. Associated gene sets

GO_0001732Biological processformation of cytoplasmic translation initiation complex
GO_0006413Biological processtranslational initiation
GO_0033290Cellular componenteukaryotic 48S preinitiation complex
GO_0016282Cellular componenteukaryotic 43S preinitiation complex
GO_0005852Cellular componenteukaryotic translation initiation factor 3 complex
GO_0003743Molecular functiontranslation initiation factor activity
GO_0031369Molecular functiontranslation initiation factor binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEIF3CL
Protein nameEukaryotic translation initiation factor 3 subunit C-like protein
Synonyms
DescriptionFUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. .

AccessionsENST00000398944.7
B5ME19
ENST00000380876.5