EHD2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EHD2 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0072659Biological processprotein localization to plasma membrane
GO_0006897Biological processendocytosis
GO_0097320Biological processplasma membrane tubulation
GO_0032456Biological processendocytic recycling
GO_1901741Biological processpositive regulation of myoblast fusion
GO_2001137Biological processpositive regulation of endocytic recycling
GO_0030866Biological processcortical actin cytoskeleton organization
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0016020Cellular componentmembrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0045171Cellular componentintercellular bridge
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005901Cellular componentcaveola
GO_0005634Cellular componentnucleus
GO_0019904Molecular functionprotein domain specific binding
GO_0003676Molecular functionnucleic acid binding
GO_0016787Molecular functionhydrolase activity
GO_0042802Molecular functionidentical protein binding
GO_0005525Molecular functionGTP binding
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEHD2
Protein nameEH domain-containing protein 2 (PAST homolog 2)
EH domain containing 2
SynonymsPAST2
DescriptionFUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes . Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane . .

AccessionsENST00000596225.5
ENST00000538399.1 [Q9NZN4-2]
M0R1B9
ENST00000263277.8 [Q9NZN4-1]
Q9NZN4