EGR2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EGR2 at tissue level.

III. Associated gene sets

GO_0007622Biological processrhythmic behavior
GO_0016925Biological processprotein sumoylation
GO_0021660Biological processrhombomere 3 formation
GO_0035904Biological processaorta development
GO_0014037Biological processSchwann cell differentiation
GO_0006611Biological processprotein export from nucleus
GO_0042552Biological processmyelination
GO_0007611Biological processlearning or memory
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0021666Biological processrhombomere 5 formation
GO_0032868Biological processresponse to insulin
GO_0014040Biological processpositive regulation of Schwann cell differentiation
GO_0021612Biological processfacial nerve structural organization
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007422Biological processperipheral nervous system development
GO_0021659Biological processrhombomere 3 structural organization
GO_0007420Biological processbrain development
GO_0008045Biological processmotor neuron axon guidance
GO_0010467Biological processgene expression
GO_0031643Biological processpositive regulation of myelination
GO_0035914Biological processskeletal muscle cell differentiation
GO_0035284Biological processbrain segmentation
GO_0021665Biological processrhombomere 5 structural organization
GO_0030278Biological processregulation of ossification
GO_0045444Biological processfat cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0061665Molecular functionSUMO ligase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0071837Molecular functionHMG box domain binding

IV. Literature review

[source]
Gene nameEGR2
Protein nameE3 SUMO-protein ligase EGR2 (E3 SUMO-protein transferase ERG2) (Early growth response protein 2)
Early growth response 2 isoform 1
Early growth response 2
E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (AT591) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20)
E3 SUMO-protein ligase EGR2
SynonymsKROX20
DescriptionFUNCTION: Sequence-specific DNA-binding transcription factor . Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity). .; FUNCTION: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. .

FUNCTION: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. .

FUNCTION: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. .

AccessionsENST00000690143.1
A0A8I5QL03
A0A0S2Z3U4
A0A8I5KVU0
A0A8I5KYI5
ENST00000411732.4 [P11161-2]
ENST00000691610.1
ENST00000439032.6
ENST00000637191.2 [P11161-1]
A0A0S2Z3Q5
ENST00000637191
ENST00000242480.4 [P11161-1]
A0A1B0GUL0
P11161