EFNB3 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	24% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of EFNB3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	92%	2752.22	2425 / 2642	99%	56.03	701 / 705
ovary	78%	726.07	140 / 180	80%	16.33	346 / 430
skin	96%	614.37	1739 / 1809	53%	10.75	251 / 472
prostate	82%	348.88	200 / 245	50%	3.99	250 / 502
breast	75%	397.94	344 / 459	53%	6.59	589 / 1118
uterus	92%	1137.15	156 / 170	25%	7.53	115 / 459
lung	37%	123.32	215 / 578	40%	4.96	462 / 1155
kidney	45%	120.70	40 / 89	27%	4.18	246 / 901
adrenal gland	11%	39.17	28 / 258	52%	27.57	119 / 230
esophagus	34%	100.71	490 / 1445	28%	3.68	51 / 183
pancreas	11%	22.25	36 / 328	47%	9.88	84 / 178
bladder	24%	73.90	5 / 21	30%	4.34	153 / 504
adipose	51%	272.90	610 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	50%	4.18	40 / 80
thymus	17%	33.52	109 / 653	19%	1.62	112 / 605
intestine	25%	55.70	246 / 966	7%	0.64	38 / 527
stomach	17%	36.39	62 / 359	11%	0.87	32 / 286
liver	24%	50.09	54 / 226	3%	0.39	13 / 406
tonsil	0%	0	0 / 0	18%	1.05	8 / 45
heart	16%	51.07	142 / 861	0%	0	0 / 0
blood vessel	2%	6.84	27 / 1335	0%	0	0 / 0
peripheral blood	0%	0.79	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007628	Biological process	adult walking behavior
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0016198	Biological process	axon choice point recognition
GO_0050771	Biological process	negative regulation of axonogenesis
GO_0031295	Biological process	T cell costimulation
GO_0099557	Biological process	trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
GO_0007267	Biological process	cell-cell signaling
GO_0046718	Biological process	symbiont entry into host cell
GO_0050806	Biological process	positive regulation of synaptic transmission
GO_1905608	Biological process	positive regulation of presynapse assembly
GO_0007399	Biological process	nervous system development
GO_0007411	Biological process	axon guidance
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0098686	Cellular component	hippocampal mossy fiber to CA3 synapse
GO_0042734	Cellular component	presynaptic membrane
GO_0046875	Molecular function	ephrin receptor binding
GO_0001618	Molecular function	virus receptor activity
GO_0005005	Molecular function	transmembrane-ephrin receptor activity
GO_0005515	Molecular function	protein binding

Gene name	EFNB3
Protein name	Ephrin-B3 (EPH-related receptor transmembrane ligand ELK-L3) (EPH-related receptor tyrosine kinase ligand 8) (LERK-8)
Synonyms	EPLG8 LERK8
Description	FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). .; FUNCTION: (Microbial infection) Acts as a receptor for nipah virus and hendra virus. .
Accessions	ENST00000226091.3 Q15768

EFNB3 report