EDEM2 | OmnibusX

Name	Number of supported studies	Average coverage
plasma cell	9 studies	33% ± 9%	Explore
macrophage	7 studies	20% ± 6%	Explore
endothelial cell	5 studies	19% ± 2%	Explore
plasmablast	3 studies	52% ± 20%	Explore
classical monocyte	3 studies	23% ± 2%	Explore
non-classical monocyte	3 studies	22% ± 6%	Explore
epithelial cell	3 studies	26% ± 8%	Explore
fibroblast	3 studies	20% ± 5%	Explore
dendritic cell	3 studies	27% ± 10%	Explore
plasmacytoid dendritic cell	3 studies	20% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of EDEM2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1106.19	1445 / 1445	100%	53.63	183 / 183
liver	100%	1815.99	226 / 226	100%	70.78	406 / 406
lung	100%	2164.88	578 / 578	100%	90.31	1155 / 1155
ovary	100%	924.30	180 / 180	100%	84.13	430 / 430
pancreas	100%	1627.84	328 / 328	100%	70.87	178 / 178
prostate	100%	1533.23	245 / 245	100%	70.13	502 / 502
skin	100%	1432.41	1809 / 1809	100%	89.98	472 / 472
stomach	100%	1059.62	359 / 359	100%	79.29	286 / 286
kidney	100%	1547.45	89 / 89	100%	71.53	900 / 901
breast	100%	1718.39	459 / 459	100%	69.83	1116 / 1118
uterus	100%	1153.31	170 / 170	100%	69.62	458 / 459
thymus	100%	1531.66	653 / 653	100%	58.54	603 / 605
intestine	100%	1334.12	966 / 966	100%	80.27	525 / 527
bladder	100%	1346.62	21 / 21	99%	82.87	501 / 504
adrenal gland	100%	2324.38	258 / 258	99%	46.32	227 / 230
brain	95%	713.01	2514 / 2642	100%	46.29	704 / 705
adipose	100%	1832.04	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	77.17	29 / 29
spleen	100%	2942.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	69.34	45 / 45
ureter	0%	0	0 / 0	100%	55.63	1 / 1
blood vessel	100%	1298.87	1332 / 1335	0%	0	0 / 0
peripheral blood	99%	2546.72	923 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	35.98	79 / 80
heart	98%	894.11	842 / 861	0%	0	0 / 0
muscle	74%	365.16	593 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1904154	Biological process	positive regulation of retrograde protein transport, ER to cytosol
GO_0005975	Biological process	carbohydrate metabolic process
GO_1904382	Biological process	mannose trimming involved in glycoprotein ERAD pathway
GO_0006986	Biological process	response to unfolded protein
GO_0006058	Biological process	mannoprotein catabolic process
GO_1904380	Biological process	endoplasmic reticulum mannose trimming
GO_0036503	Biological process	ERAD pathway
GO_0019082	Biological process	viral protein processing
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0044322	Cellular component	endoplasmic reticulum quality control compartment
GO_0004571	Molecular function	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO_0005509	Molecular function	calcium ion binding

Gene name	EDEM2
Protein name	ER degradation-enhancing alpha-mannosidase-like protein 2
Synonyms	C20orf31 C20orf49 UNQ573/PRO1135
Description	FUNCTION: Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner . May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 . Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). .
Accessions	ENST00000374491.3 [Q9BV94-2] Q9BV94 ENST00000374492.8 [Q9BV94-1]

EDEM2 report