ECSIT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061635Biological processregulation of protein complex stability
GO_0007178Biological processcell surface receptor protein serine/threonine kinase signaling pathway
GO_0051341Biological processregulation of oxidoreductase activity
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0032981Biological processmitochondrial respiratory chain complex I assembly
GO_0045087Biological processinnate immune response
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameECSIT
Protein nameECSIT signaling integrator
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)
Synonyms
DescriptionFUNCTION: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs . Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression . Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion . Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). .; FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. .

FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. .

FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. .

AccessionsENST00000592571.1
A0A8I5KR62
ENST00000252440.11 [Q9BQ95-2]
ENST00000586149.1
K7EJI1
K7ESM8
ENST00000588998.5
ENST00000688351.1 [Q9BQ95-1]
J3KTF5
K7EN32
ENST00000270517.12 [Q9BQ95-1]
ENST00000592665.1
K7EJG5
K7EPL5
ENST00000593231.1
ENST00000417981.6 [Q9BQ95-3]
Q9BQ95
ENST00000686541.1
ENST00000591104.5 [Q9BQ95-4]
K7EIK2
ENST00000690346.1 [Q9BQ95-1]
ENST00000585318.6
ENST00000592312.5
K7EM98
ENST00000590480.1