EBF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050873Biological processbrown fat cell differentiation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0060612Biological processadipose tissue development
GO_0001709Biological processcell fate determination
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameEBF2
Protein nameEBF2 protein
Transcription factor COE2 (Early B-cell factor 2) (EBF-2)
EBF transcription factor 2 (cDNA FLJ55302, highly similar to Transcription factor COE2)
SynonymsCOE2
DescriptionFUNCTION: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). .

AccessionsQ9HAK2
ENST00000520164.6 [Q9HAK2-1]
ENST00000535548.1 [Q9HAK2-2]
B7Z934
ENST00000408929.7
B2RNT0