E2F3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905461Biological processpositive regulation of vascular associated smooth muscle cell apoptotic process
GO_0070345Biological processnegative regulation of fat cell proliferation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006606Biological processprotein import into nucleus
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameE2F3
Protein nameTranscription factor E2F3 (E2F-3)
E2F transcription factor 3 isoform d
E2F transcription factor 3 isoform c
E2F3 protein
SynonymsKIAA0075
DescriptionFUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). .

AccessionsA0A3S9X9Y1
ENST00000535432.2 [O00716-2]
Q24JQ3
Q499G5
ENST00000346618.8 [O00716-1]
A0A3Q9JIX6
O00716