DZIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0061512Biological processprotein localization to cilium
GO_0007224Biological processsmoothened signaling pathway
GO_0007283Biological processspermatogenesis
GO_0007507Biological processheart development
GO_0045184Biological processestablishment of protein localization
GO_0032053Biological processciliary basal body organization
GO_0051649Biological processestablishment of localization in cell
GO_0140706Biological processprotein-containing complex localization to centriolar satellite
GO_0051220Biological processcytoplasmic sequestering of protein
GO_0120316Biological processsperm flagellum assembly
GO_0007281Biological processgerm cell development
GO_0045724Biological processpositive regulation of cilium assembly
GO_1903566Biological processpositive regulation of protein localization to cilium
GO_0032507Biological processmaintenance of protein location in cell
GO_0097539Cellular componentciliary transition fiber
GO_0034451Cellular componentcentriolar satellite
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005814Cellular componentcentriole
GO_0005737Cellular componentcytoplasm
GO_0097546Cellular componentciliary base
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0036064Cellular componentciliary basal body
GO_0005634Cellular componentnucleus
GO_0060090Molecular functionmolecular adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0062063Molecular functionBBSome binding

IV. Literature review

[source]
Gene nameDZIP1
Protein nameDZIP1 protein
Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1)
SynonymsKIAA0996
DZIP
DZIP2
DescriptionFUNCTION: Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body . At the exit of mitosis, localizes to the basal body and ciliary base of the forming primary cilium where it recruits and activates RAB8A to direct vesicle-mediated transport of proteins to the cilium (By similarity). Also recruits the BBSome, a complex involved in cilium biogenesis, by bridging it to PCM1 at the centriolar satellites of the cilium . It is also required for the recruitment to the cilium basal body of the intraflagellar transport (IFT) machinery as well as the ciliary appendage proteins CEP164 and NINEIN (By similarity). Functions as a regulator of Hedgehog signaling both through its role in cilium assembly but also probably through its ability to retain GLI3 within the cytoplasm (By similarity). It is involved in spermatogenesis through its role in organization of the basal body and assembly of the sperm flagellum . Also indirectly involved in heart development through its function in ciliogenesis . .

AccessionsENST00000361396.6 [Q86YF9-2]
Q86YF9
ENST00000466569.1 [Q86YF9-3]
ENST00000361156.7 [Q86YF9-2]
ENST00000347108.7 [Q86YF9-1]
ENST00000376829.7 [Q86YF9-1]
Q05D25