DYNC2I2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0035721Biological processintraciliary retrograde transport
GO_0042073Biological processintraciliary transport
GO_0005814Cellular componentcentriole
GO_0005930Cellular componentaxoneme
GO_0097542Cellular componentciliary tip
GO_0005813Cellular componentcentrosome
GO_0030175Cellular componentfilopodium
GO_0005929Cellular componentcilium
GO_0097014Cellular componentciliary plasm
GO_0036064Cellular componentciliary basal body
GO_0005829Cellular componentcytosol
GO_0005868Cellular componentcytoplasmic dynein complex
GO_0005737Cellular componentcytoplasm
GO_0045503Molecular functiondynein light chain binding
GO_0005515Molecular functionprotein binding
GO_0045504Molecular functiondynein heavy chain binding

IV. Literature review

[source]
Gene nameDYNC2I2
Protein nameDynein 2 intermediate chain 2
Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34)
SynonymsWDR34
DescriptionFUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system . DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis . Required also to maintain a functional transition zone . .; FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. .

AccessionsENST00000372715.7
Q96EX3
A2A3F8
ENST00000419989.2