DXO report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DXO at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DXO at tissue level.

III. Associated gene sets

GO_0071028Biological processnuclear mRNA surveillance
GO_0090304Biological processnucleic acid metabolic process
GO_0110155Biological processNAD-cap decapping
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0006402Biological processmRNA catabolic process
GO_0050779Biological processRNA destabilization
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0000287Molecular functionmagnesium ion binding
GO_0008409Molecular function5'-3' exonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0110152Molecular functionRNA NAD+-cap (NAD+-forming) hydrolase activity
GO_0034353Molecular functionmRNA 5'-diphosphatase activity
GO_0000166Molecular functionnucleotide binding

IV. Literature review

[source]
Gene nameDXO
Protein nameDecapping nuclease (EC 3.6.1.-)
Decapping and exoribonuclease protein (DXO) (EC 3.6.1.-) (5'-3' exoribonuclease DXO) (EC 3.1.13.-) (Dom-3 homolog Z) (NAD-capped RNA hydrolase DXO) (DeNADding enzyme DXO) (EC 3.6.1.-)
SynonymsDOM3Z
DOM3L
NG6
DescriptionFUNCTION: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA . The NAD-cap is present at the 5'-end of some RNAs and snoRNAs . In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay . Preferentially acts on NAD-capped transcripts in response to environmental stress . Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity). Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) . In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (By similarity). Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs . Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Exhibits decapping activity towards FAD-capped RNAs . Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). .

FUNCTION: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. .

FUNCTION: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. .

AccessionsO77932
ENST00000480240.5
ENST00000432110.5
ENST00000426498.5
F8WC68
ENST00000446967.5
ENST00000427627.1
ENST00000375349.7
ENST00000419797.6
ENST00000443250.5
ENST00000439989.5
ENST00000454430.2
ENST00000375356.7
ENST00000427690.5
ENST00000458308.5
ENST00000495340.5
H7C5D2
ENST00000337523.10
ENST00000383330.4
ENST00000399937.5
ENST00000399936.5
ENST00000414092.2
ENST00000453742.2