I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| respiratory goblet cell | 4 studies | 29% ± 5% | |
| squamous epithelial cell | 4 studies | 40% ± 11% | |
| secretory cell | 3 studies | 19% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| respiratory goblet cell | 4 studies | 29% ± 5% | |
| squamous epithelial cell | 4 studies | 40% ± 11% | |
| secretory cell | 3 studies | 19% ± 4% |
Insufficient scRNA-seq data for expression of DUOX2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 19348.96 | 651 / 653 | 85% | 189.19 | 512 / 605 |
| stomach | 79% | 7179.54 | 285 / 359 | 63% | 51.63 | 180 / 286 |
| esophagus | 47% | 2424.29 | 682 / 1445 | 77% | 77.41 | 140 / 183 |
| bladder | 76% | 2619.10 | 16 / 21 | 45% | 27.97 | 229 / 504 |
| lung | 92% | 875.31 | 533 / 578 | 25% | 12.44 | 288 / 1155 |
| intestine | 34% | 1540.74 | 332 / 966 | 71% | 61.87 | 374 / 527 |
| pancreas | 15% | 264.80 | 50 / 328 | 83% | 98.61 | 147 / 178 |
| prostate | 89% | 2100.01 | 219 / 245 | 3% | 0.59 | 16 / 502 |
| skin | 72% | 1097.27 | 1299 / 1809 | 0% | 0.13 | 2 / 472 |
| adrenal gland | 65% | 414.33 | 168 / 258 | 5% | 3.80 | 11 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 40.47 | 27 / 45 |
| uterus | 6% | 64.55 | 10 / 170 | 45% | 26.75 | 206 / 459 |
| kidney | 25% | 100.45 | 22 / 89 | 1% | 0.14 | 9 / 901 |
| liver | 11% | 92.98 | 25 / 226 | 11% | 17.30 | 44 / 406 |
| breast | 20% | 138.86 | 90 / 459 | 0% | 0.03 | 3 / 1118 |
| heart | 18% | 64.05 | 151 / 861 | 0% | 0 | 0 / 0 |
| ovary | 15% | 82.12 | 27 / 180 | 1% | 0.14 | 3 / 430 |
| blood vessel | 11% | 94.93 | 143 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 8% | 54.92 | 98 / 1204 | 0% | 0 | 0 / 0 |
| brain | 1% | 3.92 | 15 / 2642 | 0% | 0.07 | 2 / 705 |
| muscle | 0% | 1.03 | 1 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 3.32 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0042446 | Biological process | hormone biosynthetic process |
| GO_0006590 | Biological process | thyroid hormone generation |
| GO_0098869 | Biological process | cellular oxidant detoxification |
| GO_0042554 | Biological process | superoxide anion generation |
| GO_0009615 | Biological process | response to virus |
| GO_2000147 | Biological process | positive regulation of cell motility |
| GO_0042744 | Biological process | hydrogen peroxide catabolic process |
| GO_0051591 | Biological process | response to cAMP |
| GO_0050665 | Biological process | hydrogen peroxide biosynthetic process |
| GO_0042335 | Biological process | cuticle development |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0006952 | Biological process | defense response |
| GO_0090303 | Biological process | positive regulation of wound healing |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0043020 | Cellular component | NADPH oxidase complex |
| GO_0031252 | Cellular component | cell leading edge |
| GO_0009986 | Cellular component | cell surface |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0070161 | Cellular component | anchoring junction |
| GO_0045177 | Cellular component | apical part of cell |
| GO_0004601 | Molecular function | peroxidase activity |
| GO_0106294 | Molecular function | NADPH oxidase H202-forming activity |
| GO_0016174 | Molecular function | NAD(P)H oxidase H2O2-forming activity |
| GO_0020037 | Molecular function | heme binding |
| GO_0016175 | Molecular function | superoxide-generating NAD(P)H oxidase activity |
| GO_0106293 | Molecular function | NADH oxidase H202-forming activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DUOX2 |
| Protein name | Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase) Dual oxidase 2 NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) |
| Synonyms | LNOX2 THOX2 |
| Description | FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. . FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. . |
| Accessions | A0A0A8J2L3 S6CBA9 A0A0A8J1J7 S6CBA6 ENST00000389039.11 ENST00000603300.1 S6BQ37 A0A0A8J2J0 S6BAQ5 S6B486 S6BJ83 A0A0A8J1X4 X6RAN8 S6BQ40 Q9NRD8 S6B490 S6BAQ9 A0A3G5AJB3 S6BJ80 |
