DTX3L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007219Biological processNotch signaling pathway
GO_0045087Biological processinnate immune response
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0006302Biological processdouble-strand break repair
GO_0032092Biological processpositive regulation of protein binding
GO_0051607Biological processdefense response to virus
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_1902966Biological processpositive regulation of protein localization to early endosome
GO_2000646Biological processpositive regulation of receptor catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0008333Biological processendosome to lysosome transport
GO_0035563Biological processpositive regulation of chromatin binding
GO_0015031Biological processprotein transport
GO_0051444Biological processnegative regulation of ubiquitin-protein transferase activity
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0000077Biological processDNA damage checkpoint signaling
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0042393Molecular functionhistone binding
GO_0140852Molecular functionhistone ubiquitin ligase activity
GO_0097677Molecular functionSTAT family protein binding
GO_0141000Molecular functionhistone H4K91 ubiquitin ligase activity
GO_0140768Molecular functionprotein ADP-ribosyltransferase-substrate adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDTX3L
Protein nameE3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)
SynonymsBBAP
DescriptionFUNCTION: E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses . Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 . In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) . The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) . PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites . By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication . Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM . In addition, required for the recruitment of HGS and STAM to early endosomes . In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation . .

AccessionsQ8TDB6
ENST00000296161.9 [Q8TDB6-1]
ENST00000383661.3 [Q8TDB6-2]