DPP9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070269Biological processpyroptotic inflammatory response
GO_0006508Biological processproteolysis
GO_0043069Biological processnegative regulation of programmed cell death
GO_0005829Cellular componentcytosol
GO_0005874Cellular componentmicrotubule
GO_0031252Cellular componentcell leading edge
GO_0005634Cellular componentnucleus
GO_0008236Molecular functionserine-type peptidase activity
GO_0008239Molecular functiondipeptidyl-peptidase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0004177Molecular functionaminopeptidase activity

IV. Literature review

[source]
Gene nameDPP9
Protein nameDipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)
dipeptidyl-peptidase IV (EC 3.4.14.5)
Dipeptidyl peptidase 9
SynonymsDPRP2
DescriptionFUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 . Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 . Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation . The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition . .

AccessionsENST00000646573.2
ENST00000601130.5
ENST00000600621.5
ENST00000597849.5
M0R2A8
M0R2G6
ENST00000593973.2 [Q86TI2-1]
ENST00000594671.5 [Q86TI2-4]
A0A8V8TR99
ENST00000262960.14 [Q86TI2-2]
Q86TI2
M0QZ97
ENST00000601130.6 [Q86TI2-2]
A0A2R8YF65
M0R145
ENST00000598800.5 [Q86TI2-1]
ENST00000703254.1
ENST00000600556.5
ENST00000600621.6 [Q86TI2-2]