Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 6 studies | 18% ± 2% | |
epithelial cell | 5 studies | 23% ± 8% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 19% ± 2% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 19% ± 2% | |
myeloid cell | 4 studies | 17% ± 1% | |
type I pneumocyte | 4 studies | 20% ± 5% | |
macrophage | 4 studies | 20% ± 2% | |
hepatocyte | 3 studies | 24% ± 9% | |
dendritic cell | 3 studies | 30% ± 9% | |
natural killer cell | 3 studies | 20% ± 4% | |
abnormal cell | 3 studies | 20% ± 3% | |
alveolar macrophage | 3 studies | 18% ± 3% | |
astrocyte | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4027.22 | 1445 / 1445 | 100% | 41.69 | 183 / 183 |
liver | 100% | 5544.59 | 226 / 226 | 100% | 27.20 | 406 / 406 |
skin | 100% | 4744.75 | 1809 / 1809 | 100% | 36.75 | 472 / 472 |
stomach | 100% | 3098.20 | 359 / 359 | 100% | 35.37 | 286 / 286 |
thymus | 100% | 3514.17 | 653 / 653 | 100% | 20.20 | 605 / 605 |
uterus | 100% | 3612.06 | 170 / 170 | 100% | 26.55 | 459 / 459 |
lung | 100% | 4971.31 | 578 / 578 | 100% | 30.86 | 1154 / 1155 |
intestine | 100% | 4468.21 | 966 / 966 | 100% | 32.33 | 526 / 527 |
kidney | 100% | 2809.20 | 89 / 89 | 100% | 26.62 | 898 / 901 |
bladder | 100% | 4283.33 | 21 / 21 | 100% | 29.24 | 502 / 504 |
breast | 100% | 3826.61 | 459 / 459 | 99% | 29.50 | 1112 / 1118 |
prostate | 100% | 3795.18 | 245 / 245 | 99% | 16.54 | 499 / 502 |
ovary | 100% | 3066.76 | 180 / 180 | 99% | 19.56 | 426 / 430 |
adrenal gland | 100% | 2913.90 | 258 / 258 | 99% | 16.47 | 227 / 230 |
pancreas | 100% | 2151.72 | 327 / 328 | 99% | 27.15 | 176 / 178 |
brain | 99% | 1767.38 | 2606 / 2642 | 100% | 17.98 | 704 / 705 |
adipose | 100% | 3687.19 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 21.40 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 34.83 | 29 / 29 |
muscle | 100% | 7407.02 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5342.06 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 29.89 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 18.01 | 1 / 1 |
blood vessel | 100% | 3531.44 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 3134.72 | 860 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 3229.83 | 915 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070269 | Biological process | pyroptotic inflammatory response |
GO_0006508 | Biological process | proteolysis |
GO_0043069 | Biological process | negative regulation of programmed cell death |
GO_0005829 | Cellular component | cytosol |
GO_0005874 | Cellular component | microtubule |
GO_0031252 | Cellular component | cell leading edge |
GO_0005634 | Cellular component | nucleus |
GO_0008236 | Molecular function | serine-type peptidase activity |
GO_0008239 | Molecular function | dipeptidyl-peptidase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0004177 | Molecular function | aminopeptidase activity |
Gene name | DPP9 |
Protein name | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) dipeptidyl-peptidase IV (EC 3.4.14.5) Dipeptidyl peptidase 9 |
Synonyms | DPRP2 |
Description | FUNCTION: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 . Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 . Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation . The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition . . |
Accessions | ENST00000646573.2 ENST00000601130.5 ENST00000600621.5 ENST00000597849.5 M0R2A8 M0R2G6 ENST00000593973.2 [Q86TI2-1] ENST00000594671.5 [Q86TI2-4] A0A8V8TR99 ENST00000262960.14 [Q86TI2-2] Q86TI2 M0QZ97 ENST00000601130.6 [Q86TI2-2] A0A2R8YF65 M0R145 ENST00000598800.5 [Q86TI2-1] ENST00000703254.1 ENST00000600556.5 ENST00000600621.6 [Q86TI2-2] |