DOT1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0032259Biological processmethylation
GO_0031507Biological processheterochromatin formation
GO_0032200Biological processtelomere organization
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0010467Biological processgene expression
GO_0046425Biological processregulation of receptor signaling pathway via JAK-STAT
GO_2000677Biological processregulation of transcription regulatory region DNA binding
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000077Biological processDNA damage checkpoint signaling
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0140956Molecular functionhistone H3K79 trimethyltransferase activity
GO_0003676Molecular functionnucleic acid binding
GO_0031151Molecular functionhistone H3K79 methyltransferase activity
GO_0042054Molecular functionhistone methyltransferase activity
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDOT1L
Protein nameHistone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
DOT1 like histone lysine methyltransferase
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (Histone H3-K79 methyltransferase)
SynonymsKMT4
KIAA1814
DescriptionFUNCTION: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones . Binds to DNA . .

FUNCTION: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. .; FUNCTION: Histone methyltransferase. Methylates 'Lys-79' of histone H3. .

FUNCTION: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. .; FUNCTION: Histone methyltransferase. Methylates 'Lys-79' of histone H3. .

FUNCTION: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. .; FUNCTION: Histone methyltransferase. Methylates 'Lys-79' of histone H3. .

FUNCTION: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. .

AccessionsENST00000457590.2
A0A1C9J735
A0A1C9J732
Q8TEK3
H7C2S2
ENST00000452696.5
A0A087X1A7
ENST00000398665.8 [Q8TEK3-2]
ENST00000478937.3
A0A8I5QL06
C9JH95
V9GY76
ENST00000686010.1
ENST00000586024.1