DOK4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DOK4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DOK4 at tissue level.

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0007399Biological processnervous system development
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDOK4
Protein nameDocking protein 4
Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)
Synonyms
DescriptionFUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. .

AccessionsH3BSK0
ENST00000569250.5
H3BST9
ENST00000566936.5
ENST00000568617.5
ENST00000567276.5
H3BTI7
H3BS85
H3BV67
ENST00000569538.5
A0A1B0GX86
ENST00000562737.5
ENST00000566705.5
H3BTI4
ENST00000564378.5
H3BQ19
ENST00000569548.5
H3BPY9
ENST00000561659.5
H3BTK2
ENST00000567175.1
ENST00000566588.5
ENST00000340099.10
ENST00000562008.5
ENST00000567214.5
ENST00000569010.5
H3BVB4
H3BN90
Q8TEW6