DNASE1L3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DNASE1L3 at tissue level.

III. Associated gene sets

GO_0070948Biological processregulation of neutrophil mediated cytotoxicity
GO_0010623Biological processprogrammed cell death involved in cell development
GO_0006309Biological processapoptotic DNA fragmentation
GO_0002673Biological processregulation of acute inflammatory response
GO_0006259Biological processDNA metabolic process
GO_0002283Biological processneutrophil activation involved in immune response
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004536Molecular functionDNA nuclease activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0004530Molecular functiondeoxyribonuclease I activity

IV. Literature review

[source]
Gene nameDNASE1L3
Protein nameDeoxyribonuclease 1 like 3
Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD)
Deoxyribonuclease
SynonymsDNAS1L3
DHP2
DescriptionFUNCTION: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA . Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis . The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity . Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). .

AccessionsENST00000461914.7
C9J0L2
Q13609
C9J9N0
ENST00000483681.5
ENST00000460422.1
ENST00000477209.5
ENST00000486455.5 [Q13609-2]
H7C4R7
A0A0A0MT68
ENST00000394549.7 [Q13609-1]