I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| interneuron | 3 studies | 30% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| interneuron | 3 studies | 30% ± 12% |
Insufficient scRNA-seq data for expression of DISP3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 717.05 | 2613 / 2642 | 97% | 20.37 | 684 / 705 |
| prostate | 53% | 89.33 | 131 / 245 | 58% | 1.29 | 291 / 502 |
| adrenal gland | 10% | 12.10 | 27 / 258 | 52% | 2.36 | 119 / 230 |
| pancreas | 27% | 33.21 | 90 / 328 | 14% | 0.82 | 25 / 178 |
| uterus | 3% | 4.09 | 5 / 170 | 29% | 1.16 | 131 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 0.96 | 13 / 45 |
| breast | 2% | 2.46 | 11 / 459 | 26% | 0.80 | 288 / 1118 |
| spleen | 26% | 23.44 | 63 / 241 | 0% | 0 | 0 / 0 |
| ovary | 3% | 3.43 | 6 / 180 | 17% | 0.85 | 72 / 430 |
| lung | 1% | 1.39 | 7 / 578 | 11% | 0.36 | 130 / 1155 |
| intestine | 7% | 5.75 | 66 / 966 | 4% | 0.10 | 23 / 527 |
| bladder | 0% | 0 | 0 / 21 | 9% | 0.28 | 45 / 504 |
| thymus | 1% | 0.48 | 4 / 653 | 8% | 0.30 | 50 / 605 |
| esophagus | 0% | 0.96 | 3 / 1445 | 8% | 0.33 | 15 / 183 |
| kidney | 3% | 5.43 | 3 / 89 | 4% | 0.09 | 32 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.34 | 2 / 29 |
| stomach | 1% | 1.44 | 5 / 359 | 5% | 0.13 | 15 / 286 |
| skin | 0% | 0.35 | 5 / 1809 | 6% | 0.26 | 28 / 472 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.19 | 4 / 80 |
| liver | 0% | 0 | 0 / 226 | 3% | 0.07 | 12 / 406 |
| peripheral blood | 1% | 3.30 | 13 / 929 | 0% | 0 | 0 / 0 |
| muscle | 1% | 1.63 | 11 / 803 | 0% | 0 | 0 / 0 |
| heart | 1% | 1.86 | 8 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 1.05 | 6 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0.24 | 1 / 1204 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_2000179 | Biological process | positive regulation of neural precursor cell proliferation |
| GO_0030154 | Biological process | cell differentiation |
| GO_0045834 | Biological process | positive regulation of lipid metabolic process |
| GO_0032368 | Biological process | regulation of lipid transport |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0003674 | Molecular function | molecular_function |
| Gene name | DISP3 |
| Protein name | Protein dispatched homolog 3 (Patched domain-containing protein 2) Patched domain-containing protein 2 Dispatched RND transporter family member 3 |
| Synonyms | KIAA1337 PTCHD2 |
| Description | FUNCTION: Plays a role in neuronal proliferation and differentiation . Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation . May contribute to cholesterol homeostasis in neuronal cells (By similarity). . |
| Accessions | Q9P2K9 ENST00000294484.7 [Q9P2K9-1] F1T0I3 Q9UJD7 ENST00000304391.6 |
